17288-53-8

Basic information

• Product Name: 5-METHOXY-6-AZAINDOLE
• Synonyms: 5-METHOXY-6-AZAINDOLE;5-Methoxy-1H-pyrrolo[2,3-c]pyridine;5-Methxy-6-azaindole;1H-Pyrrolo[2,3-c]pyridine, 5-Methoxy-;5-Metho×y-1H-pyrrolo[2,3-c]pyridine;5-Methyl-1H-pyrrolo[2,3-c]pyridine;5-Methoxy-6-azaindole 96%
• CAS NO: 17288-53-8
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16192
• Product Categories: Azaindoles;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Indoles;Heterocycle-Pyridine series
• Mol File: 17288-53-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 122-127 °C
• Boiling Point: 304℃
• Flash Point: 105℃
• Appearance: /
• Density: 1.244
• Vapor Pressure: 0.0016mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: 2-8°C
• PKA: 14.36±0.40(Predicted)
• CAS DataBase Reference: 5-METHOXY-6-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-6-AZAINDOLE(17288-53-8)
• EPA Substance Registry System: 5-METHOXY-6-AZAINDOLE(17288-53-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 17288-53-8(Hazardous Substances Data)

Usage

Description

5-Methoxy-6-azaindole is an organic compound with the molecular formula C9H9N2O. It is a derivative of indole, featuring a methoxy group at the 5th position and an additional nitrogen atom at the 6th position, which distinguishes it as an azaindole. 5-Methoxy-6-azaindole is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
5-Methoxy-6-azaindole is used as a reactant for the preparation of indole sulfonamides, which serve as HIV entry inhibitors. These compounds play a crucial role in the development of medications aimed at preventing the human immunodeficiency virus (HIV) from entering host cells, thus helping to combat the spread of the virus.
5-Methoxy-6-azaindole is also used as a reactant for the synthesis of melatoninergic ligands, including those with an azaindole moiety. Melatoninergic ligands are compounds that interact with melatonin receptors, which are involved in the regulation of sleep-wake cycles, mood, and other physiological processes. The development of such ligands can lead to the creation of novel treatments for various sleep disorders, mood disorders, and other conditions related to the melatonin system.

InChI:InChI=1/C8H8N2O/c1-11-8-4-6-2-3-9-7(6)5-10-8/h2-5,9H,1H3

Upstream product

• 21901-41-7 4-methyl-5-nitropyridin-2(1H)-one 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 227180-23-6 3-formyl-5-methoxy-1H-pyrrolo<2,3-c>pyridine 
• 1175015-12-9 4-[2-(3-fluoro-2-methyl-benzyl)-5-methoxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1175015-10-7 4-(2-chloro-5-methoxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1175015-09-4 2-chloro-5-methoxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid 
• 1175015-08-3 2-chloro-5-methoxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-3-carbaldehyde 
• 1175015-07-2 5-methoxy-1-phenyl-1,3-dihydro-pyrrolo[2,3-c]pyridin-2-one 
• 1175015-06-1 5-methoxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine 

Relevant articles and documents

ISOTOPICALLY LABELED BIARYL UREA COMPOUNDS

The present invention is directed to isotopically labeled biaryl urea compounds which possess high affinity to neurofibrillary tangles (NFTs), and thus are useful to determine the amount and distribution of NFTs in brain. The isotopically labeled biaryl urea compounds may also be useful as PET tracers and in competition assays to identify other compounds that may serve as PET tracers.