172992-24-4

Basic information

• Product Name: tri-Z-N¹-mono-Boc-spermine
• Synonyms: tri-Z-N¹-mono-Boc-spermine
• CAS NO: 172992-24-4
• Molecular Weight: 704.864
• Mol File: 172992-24-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tri-Z-N¹-mono-Boc-spermine(CAS DataBase Reference)
• NIST Chemistry Reference: tri-Z-N¹-mono-Boc-spermine(172992-24-4)
• EPA Substance Registry System: tri-Z-N¹-mono-Boc-spermine(172992-24-4)

Safety Data

• Hazardous Substances Data: 172992-24-4(Hazardous Substances Data)

Upstream product

• 71-44-3 Spermine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 501-53-1 benzyl chloroformate 
• 132502-59-1 tert-butyl [3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]carbamate 

Downstream Products

• 172992-26-6 (3-Benzyloxycarbonylamino-propyl)-(4-{benzyloxycarbonyl-[3-(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylamino)-propyl]-amino}-butyl)-carbamic acid benzyl ester 
• 172992-39-1 (3-Benzyloxycarbonylamino-propyl)-[4-(benzyloxycarbonyl-{3-[(S)-3-(4-benzyloxy-phenyl)-2-butyrylamino-propionylamino]-propyl}-amino)-butyl]-carbamic acid benzyl ester 
• 172992-28-8 (3-Benzyloxycarbonylamino-propyl)-[4-(benzyloxycarbonyl-{3-[(5-{(S)-2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentyl)-(4,4,4-trifluoro-butyryl)-amino]-propyl}-amino)-butyl]-carbamic acid benzyl ester 
• 115976-93-7 philanthotoxin-343 
• 172992-25-5 N¹,N⁴,N⁹-tri-benzyloxycarbonyl-spermine 

Relevant articles and documents

Inhibition of growth of B16 murine melanoma cells by novel spermine analogues

To develop new cytotoxins, which could find use as anti-cancer agents, polyamine conjugates were synthesized containing spermine and an anthracene or acridine unit. Spermine is known to groove-bind to DNA; anthracene and acridine are known to intercalate. It was hoped that these polyamine-polyaromatic conjugates would use both modes of binding. Studies of growth inhibition of B16 murine melanoma cells showed the conjuates to be more effective than either spermine, anthracene-9-carboxylic acid or acridine-9-carboxylic acid, and of the conjugates, the acridine derivative showed greatest activity.