173066-60-9

Basic information

• Product Name: (2R,4R,4aS,7R,7aR)-4-(Bis-ethylsulfanyl-methyl)-7-hydroxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,2-d][1,3]dioxin-6-one
• CAS NO: 173066-60-9
• Molecular Weight: 400.517
• Mol File: 173066-60-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4R,4aS,7R,7aR)-4-(Bis-ethylsulfanyl-methyl)-7-hydroxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,2-d][1,3]dioxin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R,4aS,7R,7aR)-4-(Bis-ethylsulfanyl-methyl)-7-hydroxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,2-d][1,3]dioxin-6-one(173066-60-9)
• EPA Substance Registry System: (2R,4R,4aS,7R,7aR)-4-(Bis-ethylsulfanyl-methyl)-7-hydroxy-2-(4-methoxy-phenyl)-tetrahydro-furo[3,2-d][1,3]dioxin-6-one(173066-60-9)

Safety Data

• Hazardous Substances Data: 173066-60-9(Hazardous Substances Data)

Upstream product

• 14362-29-9 α-D-glucurono-γ-lactone 
• 3067-56-9 D-glucurono-3,6-lactone acetonide 
• 173239-81-1 (3R,4R,5S)-5-((R)-2,2-Bis-ethylsulfanyl-1-hydroxy-ethyl)-3,4-dihydroxy-dihydro-furan-2-one 
• 103357-81-9 5-O-trifluoromethanesulfonyl-1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone 
• 123-11-5 4-methoxy-benzaldehyde 
• 173066-58-5 Acetic acid (2S,3S,4R)-4-acetoxy-2-((R)-1-acetoxy-2,2-bis-ethylsulfanyl-ethyl)-5-oxo-tetrahydro-furan-3-yl ester 

Downstream Products

• 173066-62-1 Benzoic acid (1S,2S,3R)-2-benzyloxy-1-[(R)-2,2-bis-ethylsulfanyl-1-(4-methoxy-benzyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-3-methylcarbamoyl-propyl ester 
• 173066-59-6 Benzoic acid (2R,4R,5S,6S)-4-(bis-ethylsulfanyl-methyl)-6-[(R)-(tert-butyl-diphenyl-silanyloxy)-methylcarbamoyl-methyl]-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl ester 
• 173066-61-0 Benzoic acid (1S,2S,3R)-1-[(R)-2,2-bis-ethylsulfanyl-1-(4-methoxy-benzyloxy)-ethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-methylcarbamoyl-propyl ester 
• 173066-69-8 (R)-2-[(2R,4S,5S,6R)-6-(Bis-ethylsulfanyl-methyl)-5-hydroxy-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-2-(tert-butyl-diphenyl-silanyloxy)-N-methyl-acetamide 
• 173066-64-3 Benzoic acid (1S,2R)-1-((1R,2R)-1-benzyloxy-2-hydroxy-2-methylcarbamoyl-ethyl)-3,3-bis-ethylsulfanyl-2-(4-methoxy-benzyloxy)-propyl ester 

Relevant articles and documents

Regioselective Synthesis of Derivatives of L-Idopyranuronic Acid: A Key Constituent of Glycosaminoglycans

Synthesis of new and potentially universal L-idopyranuronic glycosyl-donor and/or -acceptor 13 was performed starting from D-glucofuranurono-6,3-lactone 1.After simple C-5-epimerization, C-1-thioacetalization and regioselective p-methoxybenzylidenation to the hydroxylactone 6, the lactone ring was opened.The resulting diolamide stereoselectively protected, providing compound 7.Regioselective reductive cleavage of the 1,3-dioxane ring and subsequent deprotection afforded the target molecule 13.