17311-31-8

Basic information

• Product Name: 2,3-Quinoxalinedimethanol,1,4-dioxide
• Synonyms: 2,3-Bis(hydroxymethyl)quinoxaline-1,4-di-N-oxide;2,3-Di(hydroxymethyl)quinoxaline 1,4-di-N-oxide;2,3-Di(hydroxymethyl)quinoxalinedi-N-oxide;Dioxidine;Dioxydine
• CAS NO: 17311-31-8
• Molecular Formula: C₁₀H₁₀N₂O₄
• Molecular Weight: 222.1974
• Product Categories: Custom synthesis
• Mol File: 17311-31-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 171-172℃
• Boiling Point: 365.61°C (rough estimate)
• Appearance: /
• Density: 1.50 g/cm³
• Refractive Index: 1.6620 (estimate)
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 11.05±0.10(Predicted)
• CAS DataBase Reference: 2,3-Quinoxalinedimethanol,1,4-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Quinoxalinedimethanol,1,4-dioxide(17311-31-8)
• EPA Substance Registry System: 2,3-Quinoxalinedimethanol,1,4-dioxide(17311-31-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 17311-31-8(Hazardous Substances Data)

Usage

Description

2,3-Quinoxalinedimethanol,1,4-dioxide is an organic compound with the molecular formula C8H8N2O4. It is a derivative of quinoxaline, which is a heterocyclic compound consisting of a fused benzene and pyrazine ring. 2,3-Quinoxalinedimethanol,1,4-dioxide has two hydroxyl groups attached to the 2nd and 3rd carbon atoms and a dioxide group at the 1,4-positions.

Uses

Used in Pharmaceutical Industry:
2,3-Quinoxalinedimethanol,1,4-dioxide is used as an intermediate compound for the synthesis of various pharmaceutical agents. Its unique structure allows for the development of new drugs with potential applications in treating different diseases.
Used in Antitubercular Applications:
2,3-Quinoxalinedimethanol,1,4-dioxide is used as an identifier for triazole and imidazole derivatives that have potential as antitubercular agents. Its ability to interact with these derivatives helps in the development of new drugs for the treatment of tuberculosis.
Used in Chemical Research:
2,3-Quinoxalinedimethanol,1,4-dioxide is also used in chemical research for understanding the properties and reactivity of quinoxaline derivatives. This knowledge can be applied to the design and synthesis of new compounds with specific applications in various industries.

InChI:InChI=1/C10H10N2O4/c13-5-9-10(6-14)12(16)8-4-2-1-3-7(8)11(9)15/h1-4,13-14H,5-6H2

Upstream product

• 3138-86-1 2,3-bis(bromomethyl)quinoxaline 
• 18080-67-6 2,3-bis(bromomethyl)quinoxaline 1,4-di-N-oxide 
• 2379-55-7 2,3-dimethylquinoxaline 
• 95-54-5 1,2-diamino-benzene 
• 7065-97-6 2,3-bis(hydroxymethyl)quinoxaline 
• 10103-89-6 2,3-bis(acetoxymethyl)-quinoxaline-1,4-di-N-oxide 

Downstream Products

• 3138-76-9 quinoxaline dicarboxyaldehyde-2,3 
• 15804-19-0 quinoxaline-2,3-dione 
• 95690-29-2 2-Hydroxymethyl-3-oxo-3,4-dihydroquinoxaline 1-N-oxide 

Relevant articles and documents

Preparation method of 2, 3-quinoxaline-1, 4-dioxide

The invention discloses a preparation method of 2, 3-quinoxaline-1, 4-dioxide, and belongs to the field of synthesis of medical intermediates. The method comprises the following steps: performing condensation cyclization on 1, 2-phenylenediamine serving as a raw material and 2, 3-butanedione to obtain 2, 3-dimethyl quinoxaline, and oxidizing the 2, 3-dimethyl quinoxaline with hydrogen peroxide under the action of a catalyst to obtain 2, 3-dimethyl quinoxaline-1, 4-dioxide; carrying out rearrangement and hydrolysis on the 2, 3-dimethyl quinoxaline-1, 4-dioxide and acid anhydride to obtain 2, 3-quinoxaline dimethanol; and finally, oxidizing the 2, 3-quinoxaline-1, 4-dioxide with hydrogen peroxide under the action of a catalyst to obtain the 2, 3-quinoxaline-1, 4-dioxide. By adopting the process route, the initial raw materials are easy to obtain, the cost is low, the total yield is as high as 64%, and industrial operation is facilitated.