17321-94-7

Basic information

• Product Name: 4-tert-butylpyriMidin-2-aMine
• Synonyms: 4-tert-butylpyriMidin-2-aMine
• CAS NO: 17321-94-7
• Molecular Formula: C₈H₁₃N₃
• Molecular Weight: 151.20892
• Mol File: 17321-94-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-tert-butylpyriMidin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-butylpyriMidin-2-aMine(17321-94-7)
• EPA Substance Registry System: 4-tert-butylpyriMidin-2-aMine(17321-94-7)

Safety Data

• Hazardous Substances Data: 17321-94-7(Hazardous Substances Data)

Upstream product

• 127958-04-7 2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid 
• 109-12-6 2-aminopyrimidine 
• 84380-38-1 S-tert-butyl O-ethyl carbonodithioate 
• 6135-14-4 1-dimethylamino-4,4-dimethyl-1-penten-3-one 
• 50-01-1 guanidine hydrochloride 
• 127957-85-1 2-Amino-4-tert-butyl-pyrimidine-5-carboxylic acid ethyl ester 
• 116344-10-6 2-dimethylaminomethylene-4,4-dimethyl-3-oxo-pentanoic acid ethyl ester 
• 593-85-1 diguanidine carbonate 
• 3438-47-9 4-tert-butyl-pyrimidine 

Relevant articles and documents

Xanthate-Mediated Incorporation of Quaternary Centers into Heteroarenes

The xanthate-mediated addition of tertiary alkyl radicals to heteroarenes enabled the easy functionalization of heteroaromatic rings as well as more decorated structures, such as marketed drugs or agrochemicals. This work provides a synthetic tool for efficiently exploring the chemical space by allowing late-stage diversification with a high tolerance toward functional groups.

COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

The Chichibabin amination of 4-phenyl- and 4-tert-butyl-pyrimidine

During a study on the amination of 4-phenylpyrimidine in potassium amide/liquid ammonia it was found that the extent to which the SN(ANRORC) mechanism operates in the amination largely depends upon whether an ammonium salt is used in quenching the reaction.The composition of the ?-adduct mixture, the structure of the open-chain intermediates, the inhibition of the SN(ANRORC) mechanism and the course of the amination in apolar solvents have been investigated.In addition, it has been found that, in the amination of 4-tert-butylpyrimidine, the SN(ANRORC) mechanism occurs to only a very limited extent.