17331-53-2

Basic information

• Product Name: thymidine 3'-benzoate
• Synonyms: thymidine 3'-benzoate;EINECS 241-352-7
• CAS NO: 17331-53-2
• Molecular Formula: C₁₇H₁₈N₂O₆
• Molecular Weight: 346.33462
• EINECS: 241-352-7
• Mol File: 17331-53-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.42g/cm³
• CAS DataBase Reference: thymidine 3'-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: thymidine 3'-benzoate(17331-53-2)
• EPA Substance Registry System: thymidine 3'-benzoate(17331-53-2)

Safety Data

• Hazardous Substances Data: 17331-53-2(Hazardous Substances Data)

Upstream product

• 220890-41-5 3'-O-benzoylthymidin-5'-yl 3-hydroxypropyl phosphonate 
• 98-88-4 benzoyl chloride 
• 64723-00-8 5'-O-(4-monomethoxytrityl)-3'-O-benzoyl-2'-deoxythymidine 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 50-89-5 thymidine 
• 76-83-5 trityl chloride 
• 35898-29-4 5'-benzoylthymidine 
• 80667-91-0 Carbonic acid (2R,3S,5R)-2-hydroxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-trimethylsilanyl-ethyl ester 
• 78635-98-0 3'-O-levulinoylthymidine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 942-89-2 Acetone O-benzoyloxime 
• 93966-64-4 3'-benzoyl-5'-O-(4,4'-dimethoxytrityl)thymidine 
• 17331-52-1 3'-O-benzoyl-5'-O-trityl-2'-O-deoxythymidine 
• 76541-04-3 3'-O-(tetrahydropyranyl)thymidine 

Downstream Products

• 73189-04-5 3'-O-triphenylmethylthymidine 
• 1608113-34-3 3’-O-benzoyl-2’-deoxythymidine-5'-dibenzylmonophosphate 
• 1608113-31-0 C₄₄H₅₃N₆O₁₄P 
• 5115-07-1 O,O-dibenzyl O-(5'-deoxythymidine-5'-yl)phosphate 
• 1608113-35-4 C₃₁H₃₀N₃O₁₂P 
• 1608113-36-5 C₄₁H₄₇N₆O₁₄P 
• 1608113-37-6 C₄₇H₅₉N₆O₁₄PS 
• 1608113-38-7 C₄₁H₅₅N₆O₁₄PS 
• 1608113-39-8 C₅₂H₆₈N₇O₁₆PS 
• 1608113-40-1 C₄₃H₅₉N₆O₁₅P 
• 1608113-41-2 C₃₈H₅₀N₅O₁₃PS 
• 1608113-42-3 C₅₀H₆₄N₇O₁₅PS 
• 1608113-44-5 C₅₃H₆₉N₈O₁₆PS 
• 1608113-86-5 C₅₂H₇₆N₇O₁₆PS 

Relevant articles and documents

Nucleotide libraries as a source of biologically relevant chemical diversity: Solution-phase synthesis

Solution-phase parallel synthesis of nucleotide library 1 consisting of 150 members is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

Renewable amberlyst-15 catalyzed highly regioselective tritylation and deprotection of sugar-based diols

Amberlyst-15 catalyzed highly regioselective tritylation of sugar-based diols was achieved under mild condition using 4,4′-dimethoxytrityl alcohol (DMTrOH). Deprotection of the corresponding DMTr group was also established by the variation to protic solvent. Meanwhile, the heterogeneous catalyst Amberlyst-15 was recycled 3 times with satisfactory retention of catalytic activity and proved its potential application in industry.

In search of Flavivirus inhibitors part 2: Tritylated, diphenylmethylated and other alkylated nucleoside analogues

Several flaviviruses, such as the yellow fever virus and the dengue virus cause severe and potentially lethal infection in man. Following up on our initial hit 3′,5′-bistritylated uridine 1, a series of alkylated nucleoside analogues were synthesized and evaluated for their in vitro antiviral activities against dengue fever virus and yellow fever virus. Hereto, alkyl and aryl groups were attached at various positions of the sugar ring combined with subtle variation of the heterocyclic base. Among the new series of derivatives, 3′,5′-di-O-trityl-5-fluoro-2′-deoxyuridine (39) was the most efficient in this series and inhibited both yellow fever virus and dengue virus replication with a 50% effective concentration (EC50) of ～1 μg/mL without considerable cytotoxicity. The other fluorinated derivatives proved more toxic. Almost all diphenylmethylated pyrimidine nucleosides with 3′,5′-di-O-benzhydryl-2′-deoxyuridine (50) as the example were endowed with strong cytotoxic effects down to 1 μg/mL.