173336-43-1

Basic information

• Product Name: 2-METHYL-2-MORPHOLIN-4-YL-PROPYLAMINE
• Synonyms: OTAVA-BB BB7020410146;2-METHYL-2-MORPHOLIN-4-YLPROPAN-1-AMINE;2-METHYL-2-MORPHOLIN-4-YL-PROPYLAMINE;AKOS BC-3122;2-Methyl-2-(4-morpholinyl)propylamine;(R)-(2,2,5,5-tetramethyl-1,3-dioxolan-4-yl)methyl acetate;(2-methyl-2-morpholin-4-ylpropyl)amine(SALTDATA: FREE);2-Methyl-2-(4-Morpholinyl)propylaMine, 97+%
• CAS NO: 173336-43-1
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 158.24
• EINECS: 604-604-1
• Product Categories: pharmacetical
• Mol File: 173336-43-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 225.8 °C at 760 mmHg
• Flash Point: 90.4 °C
• Appearance: /
• Density: 0.998 g/cm³
• Vapor Pressure: 0.0845mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-METHYL-2-MORPHOLIN-4-YL-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-2-MORPHOLIN-4-YL-PROPYLAMINE(173336-43-1)
• EPA Substance Registry System: 2-METHYL-2-MORPHOLIN-4-YL-PROPYLAMINE(173336-43-1)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• RIDADR: UN2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 173336-43-1(Hazardous Substances Data)

Usage

General Description

2-Methyl-2-morpholin-4-yl-propylamine, also known as MMMPA, is an organic compound with a chemical formula C9H20N2O. It is a clear, colorless liquid and is commonly used as a corrosion inhibitor in boiler water treatment, as well as in other industrial applications. MMMPA is also used as an intermediate in chemical synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is known for its ability to inhibit metal corrosion and to form protective films on metal surfaces, making it a valuable component in many industrial processes. Additionally, it is used as an intermediate in the production of a variety of organic compounds and can also be utilized as a curing agent for epoxy resins.

InChI:InChI=1/C8H18N2O/c1-8(2,7-9)10-3-5-11-6-4-10/h3-7,9H2,1-2H3

Upstream product

• 35666-81-0 2-methyl-2-(morpholin-4-yl)propanenitrile 
• 179873-11-1 2-methyl-2-morpholino-propionic acid amide 

Downstream Products

• 1374824-02-8 (R)-2,4,6-triisopropyl-N-((2-methyl-2-morpholinopropyl)carbamoyl)benzenesulfinamide 
• 1226788-78-8 C₁₆H₂₁ClFN₃O₃ 

Relevant articles and documents

Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)

KDM5B (also known as PLU-1 and JARID1B) is 2-oxoglutarate and Fe2+ dependent oxygenase that acts as a histone H3K4 demethylase, which is a key participant in inhibiting the expression of tumor suppressors as a drug target. Here, we present the discovery of pyrazole derivatives compound 5 by structure-based virtual screening and biochemical screening with IC50 of 9.320 μM against KDM5B, and its subsequent optimization to give 1-(4-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide (27 ab), a potent KDM5B inhibitor with IC50 of 0.0244 μM. In MKN45 cells, compound 27 ab can bind and stabilize KDM5B and induce the accumulation of H3K4me2/3, bona fide substrates of KDM5B, while keep the amount of H3K4me1, H3K9me2/3 and H3K27me2 without change. Further biological study also indicated that compound 27 ab is a potent cellular active KDM5B inhibitor that can inhibit MKN45 cell proliferation, wound healing and migration. In sum, our finding gives a novel structure for the discovery of KDM5B inhibitor and targeting KDM5B may be a new therapeutic strategy for gastric cancer treatment.

DELTA-AMINO-GAMMA-HYDROXY-OMEGA-ARYL-ALKANOIC ACID AMIDES

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