17343-07-6 Usage
Description
H-GLY-GLY-TYR-OH, also known as a tetrapeptide, is a short chain of amino acids consisting of glycine, glycine, and tyrosine. It is a white to off-white powder and has the ability to interact with tyrosinases, which are enzymes that can oxidize peptide-bound tyrosine residues.
Uses
Used in Pharmaceutical Industry:
H-GLY-GLY-TYR-OH is used as a pharmaceutical candidate for its interaction with tyrosinases. This interaction is important in the development of new drugs and therapies that target tyrosinase-related conditions.
Used in Cosmetic Industry:
H-GLY-GLY-TYR-OH is used as an active ingredient in the cosmetic industry for its potential to modulate tyrosinase activity. This can be beneficial in the development of skincare products that aim to regulate pigmentation and address issues such as hyperpigmentation and uneven skin tone.
Used in Research and Development:
H-GLY-GLY-TYR-OH is used as a research tool in the field of biochemistry and molecular biology. Its interaction with tyrosinases makes it a valuable compound for studying the structure, function, and regulation of these enzymes, which can lead to a better understanding of their role in various biological processes and the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 17343-07-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,4 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17343-07:
(7*1)+(6*7)+(5*3)+(4*4)+(3*3)+(2*0)+(1*7)=96
96 % 10 = 6
So 17343-07-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H17N3O5/c14-6-11(18)15-7-12(19)16-10(13(20)21)5-8-1-3-9(17)4-2-8/h1-4,10,17H,5-7,14H2,(H,15,18)(H,16,19)(H,20,21)
17343-07-6Relevant articles and documents
The Use of Crown Ethers in Peptide Chemistry IV. Solid Phase Synthesis of Peptides Using Peptide Fragments Nα Protected With 18-Crown-6
Botti, Paolo,Ball, Haydn L.,Rizzi, Emanuele,Lucietto, Pierluigi,Pinori, Massimo,Mascagni, Paolo
, p. 5447 - 5458 (2007/10/02)
The conditions under which peptide synthesis by the fragment condensation approach in the solid phase can be carried out using crown ethers as non-covalent protecting groups for the Nα amino group of peptides were determined.The dipeptide Gly-Gly was complexed with 18-crown-6 to establish the feasibility of this new protection scheme and to optimise the reaction conditions.Nearly quantitative incorporation of the complex onto resin-bound amino acids possessing either proline or an Nα-alkylated amino acids was achieved using DCM as the activation and coupling reactions solvent.The use of DMF as the solvent and resin-bound primary amino acids were found detrimental to the reaction yields due to the removal of the crown ether protection.Extending the length of the peptide fragment to model pentapeptide complexes bearing no reactive functionalities on the side-chain gave essentially quantitative incorporation yields in the coupling reactions to both resin-bound amino acids and short peptides.The non-covalent nature of the protection afforded by the crown molecule allowed its mild removal from resin-bound complexes by rapid treatments with 1percent DIEA solutions.Thus the continuation of chain assembly was possible.The results obtained served as the basis for extending the concept of non-covalent protection to the side chains of Lys and Arg containing peptides.