173459-80-8 Usage
Description
Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate is a chemical compound that belongs to the class of benzotriazole amino acids. These compounds are known for their versatility in the synthesis of peptides, peptidomimetics, and their conjugates. Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate, in particular, is characterized by its unique structure that incorporates a benzyl group and a carbamate functional group, making it a valuable building block in the development of various biologically active molecules.
Uses
Used in Pharmaceutical Industry:
Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate is used as a synthetic building block for the development of novel peptides and peptidomimetics. Its unique structure allows for the creation of diverse derivatives with potential applications in drug discovery and design.
Used in Chemical Research:
In the field of chemical research, Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate serves as a valuable reagent for the synthesis of various peptide derivatives, including polypeptidal benzotriazolides, aminoxypeptides, depsipeptides, and heterocyclic peptidomimetics. Its versatility in forming different types of peptide structures makes it an essential tool for researchers in the field.
Used in Fluorescent Labeling:
Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate is also used in the preparation of tagged peptides and peptidomimetics, particularly those with fluorescent labels. These labeled molecules can be employed in various biological applications, such as imaging and tracking of specific cellular processes or interactions.
Used in Conjugate Synthesis:
In addition to its applications in peptide synthesis, Benzyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate is utilized in the creation of N, O, S, and C linked peptide conjugates. These conjugates can be employed in various applications, such as drug delivery, targeting specific biological receptors, or enhancing the stability and bioavailability of therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 173459-80-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,3,4,5 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 173459-80:
(8*1)+(7*7)+(6*3)+(5*4)+(4*5)+(3*9)+(2*8)+(1*0)=158
158 % 10 = 8
So 173459-80-8 is a valid CAS Registry Number.
173459-80-8Relevant articles and documents
Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: Antiproliferative activity, molecular docking, and SAR studies
Abdel-Aal, Eatedal H.,Abdel-Sami, Zakaria K.,Abo-Dya, Nader E.,Al-Karmalawy, Ahmed A.,Diab, Rana T.
, p. 21657 - 21669 (2021/12/09)
The development of anticancer compounds targeting the colchicine-binding site of tubulin, termed colchicine-binding site inhibitors (CBSIs) is a promising research area for pharmaceutical companies and research institutes. A series of 3,5-disubstituted 1,
Chemical modification of oximes with N-protected amino acids
Barbakadze, Nana N.,Jones, Rachel A.,Rosario, Nicole Rivera,Nadaraia, Nanuli Sh,Kakhabrishvili, Meri L.,Dennis Hall,Katritzky, Alan R.
, p. 7181 - 7184 (2015/02/19)
The modification of oximes, including 5α-steroids, with N-protected amino acids, in solution phase, using benzotriazole methodology is reported.
Gabapentin hybrid peptides and bioconjugates
Lebedyeva, Iryna O.,Ostrov, David A.,Neubert, John,Steel, Peter J.,Patel, Kunal,Sileno, Sean M.,Goncalves, Kevin,Ibrahim, Mohamed A.,Alamry, Khalid A.,Katritzky, Alan R.
supporting information, p. 1479 - 1486 (2014/03/21)
Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied. Gabapentin was converted by N-acylation at its N-terminus into di-, tri-, and tetrapeptides (L-Ala-Gbp, L-Val-Gbp, L-Ala-L-Phe-Gbp, Gly-L-Ala-β-Ala-Gbp). Carboxyl-activated Boc-protected gabapentin was used to N-, O-, and S-acylate small peptides and hormones to give conjugates that could also provide prodrugs containing conformationally constrained gabapentin units.