17377-82-1

Basic information

• Product Name: 2-Propenoic acid, 3-phenyl-, 1-Methylpropyl ester, (2E)-
• Synonyms: 2-Propenoic acid, 3-phenyl-, 1-Methylpropyl ester, (2E)-
• CAS NO: 17377-82-1
• Molecular Formula: C₁₃H₁₆O₂
• Molecular Weight: 204.26494
• Mol File: 17377-82-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoic acid, 3-phenyl-, 1-Methylpropyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-phenyl-, 1-Methylpropyl ester, (2E)-(17377-82-1)
• EPA Substance Registry System: 2-Propenoic acid, 3-phenyl-, 1-Methylpropyl ester, (2E)-(17377-82-1)

Safety Data

• Hazardous Substances Data: 17377-82-1(Hazardous Substances Data)

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 78-92-2 iso-butanol 
• 102-92-1 Cinnamoyl chloride 
• 21947-71-7 cinnamic anhydride 

Downstream Products

• 96706-62-6 3,4-diphenyl-butyric acid sec-butyl ester 
• 92581-12-9 4-trans-styryl-hepta-1,6-dien-4-ol 
• 340001-71-0 4-(5-Chloro-2-methoxy-phenyl)-3-phenyl-butyric acid sec-butyl ester 
• 17913-10-9 1-methyl-3-phenyl-butanal 
• 7028-47-9 dimethyl (3SR,4SR)-3,4-diphenylhexanedioate 
• 25347-44-8 racem.-3,4-diphenyl-adipic acid 
• 13351-28-5 trans-3,4-diphenylcyclopentanone 
• 61883-07-6 meso-3,4-diphenyl-adipic acid dimethyl ester 
• 54308-33-7 4-(5-Chloro-2-methoxy-phenyl)-3-phenyl-butyric acid 
• 54308-35-9 4-(2'-Methoxyphenyl)-3-phenylbutyric acid 
• 173142-22-8 1,5-Dichloro-4,8-diphenyltricyclo[5.1.0.0^3,5]octane-2,6-dione 
• 1772-62-9 sec-Butyl-trans-3,4-diphenylcyclopentanon-2-carboxylat 
• 65610-01-7 meso-3,4-diphenyl-adipic acid 
• 16253-73-9 3-phenyl-heptanoic acid sec-butyl ester 

Relevant articles and documents

Synthesis of (E)-cinnamyl ester derivatives via a greener Steglich esterification

Cinnamic acid derivatives are known antifungal, antimicrobial, antioxidant, and anticancer compounds. We have developed a facile and mild methodology for the synthesis of (E)-cinnamate derivatives using a modified Steglich esterification of (E)-cinnamic acid. Using acetonitrile as the solvent, rather than the typical chlorinated solvent, and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) as the coupling agent enables ester conversion in 45 min with mild heating (40–45 °C) and an average yield of 70% without need for further purification. These conditions were used to couple (E)-cinnamic acid with 1° and 2° aliphatic alcohols, benzylic and allylic alcohols, and phenols. This work demonstrates a facile and greener methodology for Steglich esterification reactions.

Quantitative structure-activity relationships of pine weevil antifeedants, a multivariate approach

Antifeedant activity of mainly phenylpropanoic, cinnamic, and benzoic acids esters was tested on the pine weevil, Hylobius abietis (L.). Of 105 compounds screened for activity, 9 phenylpropanoates, 3 cinnamates, and 4 benzoates were found to be highly active antifeedants. To understand the structure-activity relationships of these compounds, a multivariate analysis study was performed. A number of molecular and substituent descriptors were calculated and correlated to results from two-choice feeding tests with H. abietis. Three local models were developed that had good internal predictive ability. External test sets showed moderate predictivity. In general, low polarity, small size, and high lipophilicity were characteristics for compounds having good antifeedant activity.

Kinetics of trans-cinnamic anhydride reactions catalyzed by pyridine, 4-dimethylaminopyridine, and N-methylimidazole

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