173853-65-1Relevant articles and documents
2-Aminopyrrole and simple 1-substituted 2-aminopyrroles: Preparation and ab initio study on the effect of solvent on the amino-imino tautomeric equilibrium
De Rosa, Michael,Issac, Roy P.,Marquez, Manuel,Orozco, Modesto,Luque, Francisco J.,Timken, Mark D.
, p. 1433 - 1437 (2007/10/03)
This work describes the preparation and NMR characterization of 2-aminopyrrole and simple 1-substituted-2-aminopyrroles without further substitution on the ring. The question of the effect of solvent on tautomerism in 2-aminopyrroles has been studied by using ab initio quantum mechanical methods. Theoretical calculations indicated that 2-aminopyrrole is the most stable form in chloroform and in water. Experimentally this is what was observed. Calculations indicated that in the case of the 1-methyl-2-aminopyrrole both amino and imino tautomers should be observable in water.
First synthesis of 2-aminopyrrole and simple 1-substituted-2-aminopyrroles. Observation of fast proton exchange at C-5
De Rosa, Michael,Issac, Roy P.,Houghton, Gregory
, p. 9261 - 9264 (2007/10/02)
N-(1-substituent-1H-pyrrol-2-yl)phthalimides can be used to prepare the previously unknown 2-aminopyrrole and 1-substituted-2-aminopyrroles which undergo fast proton exchange at C-5 in acetic acid at 25°C.
