173936-22-6

Basic information

• Product Name: (S)-1-(2,4-Difluoro-phenyl)-2-methylsulfanyl-propan-1-one
• Synonyms: (S)-1-(2,4-Difluoro-phenyl)-2-methylsulfanyl-propan-1-one
• CAS NO: 173936-22-6
• Molecular Weight: 216.252
• Mol File: 173936-22-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-(2,4-Difluoro-phenyl)-2-methylsulfanyl-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(2,4-Difluoro-phenyl)-2-methylsulfanyl-propan-1-one(173936-22-6)
• EPA Substance Registry System: (S)-1-(2,4-Difluoro-phenyl)-2-methylsulfanyl-propan-1-one(173936-22-6)

Safety Data

• Hazardous Substances Data: 173936-22-6(Hazardous Substances Data)

Downstream Products

• 173787-23-0 (E)-2-(2,4-difluorophenyl)-2-buten-1-ol 
• 173787-22-9 (E)-2-(2,4-Difluoro-phenyl)-but-2-enal 

Relevant articles and documents

Optical resolution of dl-threo-2-(2,4-difluorophenyl)-2-[1-(methylthio)ethyl]oxirane: Its application to the synthesis of SM-9164, a biologically active enantiomer of antifungal agent SM-8668

A racemate of threo-2-(2,4-difluorophenyl)-2-[1-(methylthio)ethyl]oxirane was separated into two enantiomers by reaction with a chiral carboxylic acid, followed by separation of the resultant diastereomers, hydrolysis of the ester, and dehydration of the 1,2-diol to the oxirane. This new optical resolution method was applied to the synthesis of SM-9164, a biologically active enantiomer of antifungal agent SM-8668. Thus, the optically active isomer of SM-8668 was prepared efficiently in eight steps from m-difluorobenzene.