173991-96-3Relevant articles and documents
Synthesis of the dolabellane diterpene hydrocarbon (±)-δ-araneosene
Jenny,Borschberg
, p. 715 - 731 (1995)
The racemic form of the bicyclic diterpene hydrocarbon δ-araneosene (4), endowed with the dolabellane skeleton, was prepared from geraniol in two different ways. The more efficient route involved 13 steps and proceeded with an overall yield of 3.6% (average: 77% per step). With this reference sample at hand, the hitherto elusive metabolite (-)-4, a likely biogenetic precursor of cycloaraneosene ((-)-3) and sordaricin ((-)-1), could finally be isolated in ≥ 99.5% purity from the neutral fractions of the mold Sordaria araneosa CAIN (Ascomycetes).