174003-17-9Relevant articles and documents
N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists
Doherty, George A.,Kamenecka, Theodore,McCauley, Ermenegilda,Van Riper, Gail,Mumford, Richard A.,Tong, Sharon,Hagmann, William K.
, p. 729 - 731 (2002)
A series of N-arylated phenylalanine derivatives has been synthesized and has been shown to be potent inhibitors of the integrin VLA-4. N-phenyl and N-heteroaryl derivatives with hydrogen bond acceptors in the meta position demonstrated low nanomolar acti
NOVEL GLP-1 RECEPTOR MODULATORS
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, (2016/02/09)
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36), GLP-1(9-36), and oxyntomodulin, or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "?" represents either or both the R and S form of the compound): where A, B, C, R1, R2, R3, R4, R5, n, p and q are as defined herein.
PPAR-γ agonists as agents for the treatment of type II diabetes
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Page/Page column 9-10, (2008/06/13)
N-(substituted)carbamoylaryl- and heteroaryl substituted aminopropanoic and butanoic acid compounds which are highly selective agonists for the PPAR-γ receptor or prodrugs of agonists for the PPAR-γ receptor, and are useful in the treatment of Type II dia