174020-29-2

Basic information

• Product Name: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-methyl-
• CAS NO: 174020-29-2
• Molecular Formula: C30H30N2O7
• Molecular Weight: 530.577
• Mol File: 174020-29-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-methyl-(174020-29-2)
• EPA Substance Registry System: Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-methyl-(174020-29-2)

Safety Data

• Hazardous Substances Data: 174020-29-2(Hazardous Substances Data)

Usage

General Description

Uridine, 5'-O-[(4-methoxyphenyl)diphenylmethyl]-3'-O-methyl- is a modified form of uridine, a natural nucleoside found in RNA. This chemical is produced by substituting the 5'-hydroxyl group with a 4-methoxyphenyl group and the 3'-hydroxyl group with a methyl group. It is commonly used in research and drug development as a biochemical tool to study nucleic acid structure and function. This modified uridine compound may have potential therapeutic applications due to its ability to interact with nucleic acids and affect cellular processes, but further research is needed to fully understand its pharmacological properties and potential uses.

Upstream product

• 186581-53-3 diazomethane 
• 51600-12-5 5'-O-monomethoxytrityluridine 

Downstream Products

• 226882-19-5 3'-O-methyl-5'-O-(monomethoxytrityl)uridine 2'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite> 
• 6038-59-1 3'-O-methyluridine 
• 174020-30-5 C₆₄H₆₁N₇O₁₂ 

Relevant articles and documents

176. Nucleosides part LXI: A simple procedure for the monomethylation of protected and unprotected ribonucleosides in the 2′-O- and 3′-O-position using diazomethane and the catalyst stannous chloride

Intensive studies on the diazomethane methylation of the common ribonucleosides uridine, cytidine, adenosine, and guanosine and its derivatives were performed to obtain preferentially the 2′-O-methyl isomers. Methylation of 5′-O-(monomethoxytrityl)-N 2-[2-(4-nitrophenyl)ethoxycarbonyl]-O 6-[2-(4-nitrophenyl)ethyl]-guanosine (1) with diazomethane resulted in an almost quantitative yield of the 2′-nd 3′-O-methyl isomers which could be separated by simple silica-gel flash chromatography (Scheme 1). Adenosine, cytidine, and uridine were methylated with diazomethane with and without protection of the 5′-O-position by a mono- or dimethoxytrityl group and the aglycone moiety of adenosine and cytidine by the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) group (Schemes 2-4). Attempts to increase the formation of the 2′-O-methyl isomer as much as possible were based upon various solvents, temperatures, catalysts, and concentration of the catalysts during the methylation reaction.