17408-17-2

Basic information

• Product Name: 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone
• Synonyms: 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone
• CAS NO: 17408-17-2
• Molecular Formula: C₈H₄F₃NO₃
• Molecular Weight: 219.1174696
• Mol File: 17408-17-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone(17408-17-2)
• EPA Substance Registry System: 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone(17408-17-2)

Safety Data

• Hazardous Substances Data: 17408-17-2(Hazardous Substances Data)

Usage

General Description

2,2,2-trifluoro-1-(2-nitrophenyl)ethanone is a chemical compound with the molecular formula C8H5F3O3. It is a highly reactive compound that is often used as a synthetic intermediate in organic chemistry. The presence of the trifluoromethyl group and the nitrophenyl moiety make it useful for creating diverse fluorinated organic compounds. It is commonly used as a reagent for the synthesis of various pharmaceuticals, agrochemicals, and materials science applications. Additionally, it is a valuable building block for the production of complex organic molecules with specific properties and functions. However, it is important to handle this compound with care, as it can be hazardous if not used properly.

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 552-89-6 2-nitro-benzaldehyde 
• 700362-32-9 2,2,2-trifluoro-1-(2-nitrophenyl) ethanol 
• 383-63-1 ethyl trifluoroacetate, 
• 577-19-5 2-nitrophenyl bromide 
• 609-73-4 o-nitroiodobenzene 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 918337-63-0 (S)-2,2,2-trifluoro-1-(2-nitrophenyl)ethanol 
• 136476-24-9 1-nitro-2-(3,3,3-trifluoroprop-1-en-2-yl) benzene 
• 351002-89-6 1-(2-amino-5-phenyl)-2,2,2-trifluoroethanone 
• 64196-43-6 2-phenyl-4-(trifluoromethyl)quinoline 
• 1566470-10-7 C₁₅H₁₀F₃NO₂ 
• 1566470-11-8 C₁₅H₁₀F₃NO₂ 
• 57631-05-7 3-(trifluoromethyl)-1H-indazole 
• 863870-47-7 2-(2,2-dibromo-1-(trifluoromethyl)vinyl)-phenylamine 
• 918337-64-1 (S)-1-(2-aminophenyl)-2,2,2-trifluoroethanol 
• 886854-02-0 1-(2,2-dibromo-1-(trifluoromethyl)vinyl)-2-nitrobenzene 
• 675106-80-6 2,2,2-trifluoro-2'-nitroacetophenone oxime 

Relevant articles and documents

A novel non-acidic method for the preparation of 2,2,2-trifluoro-1-(3-nitrophenyl)ethanone and 1-nitro-3-trifluoromethylbenzene, versatile starting materials for trifluoromethyl-containing aromatic compounds

Treatment of 2,2,2-trifluoro-1-phenylethanone (1) and α,α,α-trifluorotoluene (3) with ozone or ozonized air in chlorinated hydrocarbons in the presence of excess nitrogen dioxide and a catalytic amount of iron(III) salt at -10-0°C leads to the respective title nitro compounds 2 and 4 in good to excellent yields. The reaction is clean and rapid, little or no hydrolysis of the trifluoromethyl group being observed during the nitration.

ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P13K MODULATION

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I), or a prodrug, solvate, enantiomer, st

Oxidation of α-trifluoromethyl and non-fluorinated alcohols: Via the merger of oxoammonium cations and photoredox catalysis

We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields.