174265-38-4Relevant articles and documents
Process for the preparation of hydroxamic acid derivatives
-
, (2008/06/13)
The present invention provides an improved process for preparing an hydroxycarbamoyl derivative of a carboxylic acid using a hydroxylammonium salt of a carboxylic acid as a reagent.
Practical approaches to the matrix metalloproteinase inhibitor Trocade (Ro 32-3555) and to the TNF-α converting enzyme inhibitor Ro 32-7315
Hilpert, Hans
, p. 7675 - 7683 (2007/10/03)
Stereoselective methods were found to efficiently prepare 2- and 3-substituted succinates with anti configuration. In the synthesis of Trocade 1, the hydantoinmethyl residue was introduced by alkylation of the non-chelated potassium enolate 19 with the br
Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)
Broadhurst,Brown,Lawton,Ballantyne,Borkakoti,Bottomley,Cooper,Eatherton,Kilford,Malsher,Nixon,Lewis,Sutton,Johnson
, p. 2299 - 2302 (2007/10/03)
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.