174358-90-8

Basic information

• Product Name: 2-amino-6-(benzyloxy)-9-<<4(S)-(benzyloxy)-1-(diethylphosphonyl)-3(R)-pentoxy>methyl>purine
• CAS NO: 174358-90-8
• Molecular Weight: 583.624
• Mol File: 174358-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-6-(benzyloxy)-9-<<4(S)-(benzyloxy)-1-(diethylphosphonyl)-3(R)-pentoxy>methyl>purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6-(benzyloxy)-9-<<4(S)-(benzyloxy)-1-(diethylphosphonyl)-3(R)-pentoxy>methyl>purine(174358-90-8)
• EPA Substance Registry System: 2-amino-6-(benzyloxy)-9-<<4(S)-(benzyloxy)-1-(diethylphosphonyl)-3(R)-pentoxy>methyl>purine(174358-90-8)

Safety Data

• Hazardous Substances Data: 174358-90-8(Hazardous Substances Data)

Upstream product

• 144911-94-4 Diethyl (3R,4S)-4-(benzyloxy)-3-hydroxypentanephosphonate 
• 174359-09-2 4(S)-(benzyloxy)-3(R)-(chloromethoxy)-1-(diethylphosphonyl)pentane 
• 19916-73-5 2-Amino-6-benzyloxypurine 

Downstream Products

• 174358-91-9 9-<<4(S)-(benzyloxy)-1-(diethylphosphonyl)-3(R)-pentoxy>methyl>guanine 

Relevant articles and documents

Synthesis of phosphonate isosteres of 2′-deoxy-1′,2′-seco-nucleotides

Practical and convergent syntheses of 2′-deoxy-1′,2′-seco-nucleophosphonates and 1′,2′-seco-nucleophosphonates are described. Phosphonate chirons derived from D-isoascorbic acid were used in alkylation of functionalized nucleobases to provide the title phosphonate isosteres in good yields. Subsequent deprotection and deesterification led to the 5′-C-methylenephosphonic acids which were conveniently purified using gravity flow C18 reverse phase column chromatography.