174392-41-7

Basic information

• Product Name: N-((1S,2R)-2-Hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-acetamide
• CAS NO: 174392-41-7
• Molecular Weight: 209.245
• Mol File: 174392-41-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((1S,2R)-2-Hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1S,2R)-2-Hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-acetamide(174392-41-7)
• EPA Substance Registry System: N-((1S,2R)-2-Hydroxy-1-hydroxymethyl-2-phenyl-ethyl)-acetamide(174392-41-7)

Safety Data

• Hazardous Substances Data: 174392-41-7(Hazardous Substances Data)

Upstream product

• 174392-37-1 (1R,2S)-2-Amino-1-phenyl-but-3-en-1-ol 
• 174392-39-3 Acetic acid (1R,2S)-2-acetylamino-1-phenyl-but-3-enyl ester 
• 120443-82-5 (R)-2-phenyl-2-(trimethylsiloxy)acetonitrile 

Relevant articles and documents

Stereoselective Synthesis of (1R,2S)-2-Amino-1,3-diols from (R)-Cyanohydrins

Vinyl substituted (1R,2S)-amino alcohols 5 were obtained by addition of vinyl magnesium bromide to the corresponding cyanohydrin O-trimethylsilyl ethers (R)-2.The O- and N-protected vinyl amino alcohols 6 were ozonized at -78 deg C in methanol yielding (1R,2S)-2-amino-1,3-diols 7 in high enantiomeric and diastereomeric excesses.For purification, compounds 7 in some cases were acetylated to give the derivatives (1R,2S)-8.Racemic 6a was converted by oxidative ozonolysis at -78 deg C in methanolic NaOH solution to the corresponding methyl N-acetyl-β-hydroxy propanoate 9a.The configuration of (1R,2S)-8a was confirmed by x-ray crystallographic analysis.