17440-83-4

Basic information

• Product Name: Amiloride hydrochloride dihydrate
• Synonyms: Modamide;AMILORIDE HYDROCHLORIDE (500 MG);AMILORIDE HCL DIHYDRATE;AMILORIDE HYDROCHLORIDE 2-HYDRATE;Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride, dihydrate;AMILORIDEHYDROCHLORIDE,USP;3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride dihydrate;Amiloride hydrochloride dihydrate
• CAS NO: 17440-83-4
• Molecular Formula: C6H8ClN7O.HCl.2H2O
• Molecular Weight: 302.12
• EINECS: 217-958-2
• Product Categories: MK-870
• Mol File: 17440-83-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: >240℃
• Boiling Point: 628.1 °C at 760 mmHg
• Flash Point: 333.7 °C
• Appearance: /
• Vapor Pressure: 1.08E-15mmHg at 25°C
• Solubility: Slightly soluble in water and in anhydrous ethanol.
• PKA: 8.7(at 25℃)
• Water Solubility: Soluble in water at 50mg/ml
• CAS DataBase Reference: Amiloride hydrochloride dihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Amiloride hydrochloride dihydrate(17440-83-4)
• EPA Substance Registry System: Amiloride hydrochloride dihydrate(17440-83-4)

Safety Data

• WGK Germany: 3
• RTECS: UQ2275500
• HazardClass: 6.1
• Hazardous Substances Data: 17440-83-4(Hazardous Substances Data)

Usage

Description

Amiloride hydrochloride dihydrate is a chemical compound with the formula C6H7N7OHCl·2H2O. It is a pale yellow or greenish-yellow powder and is known for its role as a calcium channel and sodium channel protein inhibitor. Amiloride hydrochloride dihydrate is also an inhibitor of Sodium/Potassium-ATPase Protein and has the ability to block various ion channels, such as TRPP3, ASIC, and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Amiloride hydrochloride dihydrate is also known to inhibit urokinase-type plasminogen activator (uPA) without affecting tissue-type plasminogen activator. It is commonly marketed under the brand name Midamor by Merck.

Uses

Used in Pharmaceutical Industry:
Amiloride hydrochloride dihydrate is used as a diuretic and an antialdosterone agent for the treatment of conditions related to fluid and electrolyte balance, such as edema, hypertension, and heart failure. It functions by reducing the electrical potential across tubular epithelium, which in turn inhibits angiogenesis and capillary morphogenesis.
Used in Epithelial Sodium Channel Blocker Applications:
In the field of medicine, Amiloride hydrochloride dihydrate is used as an epithelial sodium channel blocker. This application is particularly useful in the treatment of conditions where the regulation of sodium and fluid balance is crucial, such as cystic fibrosis and certain kidney diseases.
Used in Research and Development:
Amiloride hydrochloride dihydrate is also utilized in research and development for studying the effects of ion channels and their role in various physiological processes. Its ability to block specific ion channels makes it a valuable tool in understanding the underlying mechanisms of certain diseases and potential therapeutic targets.

InChI:InChI=1/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2