174417-14-2Relevant articles and documents
β-Acylation of ethyl pyrrole-2-carboxylate by Friedel-Crafts acylation: Scope and limitations (synthetic studies on indoles and related compounds. XXXVIII
Tani,Ariyasu,Nishiyama,Hagiwara,Watanabe,Yokoyama,Murakami
, p. 48 - 54 (2007/10/03)
The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under several conditions using various Lewis acids and acyl chlorides. The acylation with various acyl chlorides in the presence of aluminum chloride gave exclusively ethyl 4-acylpyrrole-2-carboxylate (5), whereas weaker Lewis acids such as zinc chloride and boron trifluoride etherate gave a mixture of ethyl 4- and 5-acylpyrrole-2-carboxylates.