174422-15-2

Basic information

• Product Name: 2-(2,4-Dichloro-phenyl)-1H-benzoimidazole-5-carboxylic acid
• CAS NO: 174422-15-2
• Molecular Weight: 307.136
• Mol File: 174422-15-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,4-Dichloro-phenyl)-1H-benzoimidazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Dichloro-phenyl)-1H-benzoimidazole-5-carboxylic acid(174422-15-2)
• EPA Substance Registry System: 2-(2,4-Dichloro-phenyl)-1H-benzoimidazole-5-carboxylic acid(174422-15-2)

Safety Data

• Hazardous Substances Data: 174422-15-2(Hazardous Substances Data)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 619-05-6 3,4-diaminobenzoic acid 

Relevant articles and documents

SYNTHESIS OF 1,2-DISUBSTITUTED BENZIMIDAZOLE-5(6)-CARBOXAMIDES AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY

A series of 14,N'-(N,N-dialkylaminoethyl)-benzimidazole-5(6) or 5-carboxamides (1-14), having several substituents on the azole and benzene nuclei, were prepared and evalueted in vitro for antimicrobial activity.The precursor bezimidazolecarboxylic acids (15-27) were prepared via oxidative condensation of diaminobenzoic acids and several aldehydes with cupric ion.Compounds 11-14 were prepared by selective regioisomer synthesis.All carboxamides were prepared from the corresponding acids and N,N-dialkylethylenediamine.Antibacterial and antifungal activities were determined as MICs values.Of the synthesized compounds 1-10, 6 and 10 were found to be most favourable.In order to clarify the effect of the substituents at N1 on antimicrobial activity, 12 was prepared by p-chlorobenzyl substitution of compound 6, and increased activity was shown.Compounds 13 and 14, which were prepared by replacement with more bulky alkyl groups on the tert-N atom than 12, gave the best results.