174505-77-2

Basic information

• Product Name: 2-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-p-tolylsulfanyl-propyl]-isoindole-1,3-dione
• Synonyms: 2-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-p-tolylsulfanyl-propyl]-isoindole-1,3-dione
• CAS NO: 174505-77-2
• Molecular Weight: 439.467
• Mol File: 174505-77-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-p-tolylsulfanyl-propyl]-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-p-tolylsulfanyl-propyl]-isoindole-1,3-dione(174505-77-2)
• EPA Substance Registry System: 2-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-p-tolylsulfanyl-propyl]-isoindole-1,3-dione(174505-77-2)

Safety Data

• Hazardous Substances Data: 174505-77-2(Hazardous Substances Data)

Upstream product

• 87943-21-3 2-[3-(p-tolylthio)propyl]isoindoline-1,3-dione 
• 87943-36-0 Acetic acid 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-p-tolylsulfanyl-propyl ester 
• 58138-78-6 bis-trimethylsilyl-5-fluoro-uracil 
• 51-21-8 5-fluorouracil 
• 174505-65-8 Trifluoro-acetic acid 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-p-tolylsulfanyl-propyl ester 

Downstream Products

• 87943-14-4 2-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(toluene-4-sulfinyl)-propyl]-isoindole-1,3-dione 

Relevant articles and documents

Nucleoside analogs. 14. The synthesis and antitumor activity in mice of molecular combinations of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea moieties separated by a three-carbon chain

5-Fluorouracil (5-FU) seco-nucleosides having as the "sugar" moiety a two-carbon (C2) side chain carrying a N-(2-chloroethyl)-N-nitrosourea group were designed as molecular combinations of antimetabolite and alkylating agent, but hydrolytic release of free 5-FU was not fast enough for significant contribution to the high activity they showed against colon and breast tumors in mice. In the present study of the synthesis of the more reactive C3 seco-nucleosides, it emerged that, of various groups attached to the aldehydic center in the precursor phthalimides, only the alkoxy/uracil-1-yl type was conveniently obtained by the standard method. The methylthio/uracil-1-yl analog required relatively large amounts of reagent methanethiol, and exploration of alternatives involving α-chlorination of alkyl methyl sulfide or Pummerer rearrangement of its S-oxide, or successive hydrolysis and methylation of isothiouronium bromide, gave disappointing yields. For successful preparation of the alkoxy/ uracil-3-yl compounds, the route used for C2 homologs required considerable experimental modification. In addition to these O,N- and S,N-acetals, some N,N-acetals bearing two 5-FU residues were prepared. The new drugs have been tested against a panel of experimental tumors in mice. Although it is evident from a parallel study that even these C8 seco-nucleosides release free 5-FU too slowly in vivo, several of them have shown impressive anticancer activity. Reviewing their performance in comparison with earlier molecular combinations, a short list of seven [B.4152 (6), B.4015 (5), B.4030 (10), B.3999 (4), B.3995 (2), B.4083 (3), and B.3996 (the N3-substituted analog of 1)] should be investigated further. This is particularly appropriate in light of the present understanding of the mode of action of chloroethylating agents. Following a prolonged period of clinical impatience with nitrosoureas because of limited selectivity of action, a new era is confidently anticipated as these powerful drugs are increasingly studied in combination with O6-benzylguanine and other more efficient inhibitors of repair enzymes like O6-alkylguanine-DNA-alkyltransferase now being developed.