174537-28-1

Basic information

• Product Name: N-benzyloxycarbonyl-α-azaisoleucyl-p-nitrobenzylester
• CAS NO: 174537-28-1
• Molecular Weight: 387.392
• Mol File: 174537-28-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyloxycarbonyl-α-azaisoleucyl-p-nitrobenzylester(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloxycarbonyl-α-azaisoleucyl-p-nitrobenzylester(174537-28-1)
• EPA Substance Registry System: N-benzyloxycarbonyl-α-azaisoleucyl-p-nitrobenzylester(174537-28-1)

Safety Data

• Hazardous Substances Data: 174537-28-1(Hazardous Substances Data)

Upstream product

• 5331-43-1 N-benzyloxycarbonyl-hydrazine 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 1026406-10-9 N'-sec-Butyl-hydrazinecarboxylic acid benzyl ester 

Downstream Products

• 1027476-46-5 C₁₈H₂₉N₃O₅ 

Relevant articles and documents

Peptidyl and azapeptidyl methylketones as substrate analog inhibitors of papin and cathepsin B

Peptidyl methylketones containing Phe, Tyr, Tyr(I), Tyr(I2), Leu and Ile in P2 were synthesized and tested as substrate analog revesible of papain and bovine spleen cathepsin B.The most effective cathepsin B inhibitor contained Tyr(I2) and displayed an inhibition constant of 4.7 μM at pH 6.8 and 25 deg C, while Leu or Ile gave practically inert analogs.Replacement of the amino acids in P2 with the analogues α-azaamino acids, as well as the glycine in P1 with α-azaglycine, led to complete loss of inhibiting activity.Introducing alkoxy substituents at themethyl adjacent to the ketone group generally resulted in more effective inhibitors, with inhibition constants in the micromolar range for both papin and cathepsin B. - Keywords: enzyme inhibiting activity; cysteine proptease; slow binding; peptidyl methylketone; azapeptidyl methylketone; papain; cathepsin B