174541-86-7

Basic information

• Product Name: (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-3,5-pentandiol
• Synonyms: (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-3,5-pentandiol
• CAS NO: 174541-86-7
• Molecular Weight: 325.405
• Mol File: 174541-86-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-3,5-pentandiol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-3,5-pentandiol(174541-86-7)
• EPA Substance Registry System: (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-3,5-pentandiol(174541-86-7)

Safety Data

• Hazardous Substances Data: 174541-86-7(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 153805-41-5 methyl (4R,5R)-4-(benzyloxy)methyl-2-oxo-5-oxazolidineacetate 
• 153805-45-9 (4R,5R)-4-(benzyloxy)methyl-5-(2-hydroxyethyl)-2-oxo-oxazolidine 

Downstream Products

• 174690-66-5 1-((2R,4S,5R)-1-Acetyl-5-benzyloxymethyl-4-hydroxy-pyrrolidin-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 174577-66-3 1-((2S,4S,5R)-1-Acetyl-5-benzyloxymethyl-4-hydroxy-pyrrolidin-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 174577-61-8 Benzoic acid (1S,2R)-2-acetylamino-3-benzyloxy-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-propyl ester 
• 174577-60-7 N-[(1R,2R)-1-Benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-butyl]-acetamide 
• 174577-62-9 Benzoic acid (1S,2R)-2-acetylamino-3-benzyloxy-1-(2-hydroxy-ethyl)-propyl ester 
• 174577-59-4 N-((1R,2R)-1-Benzyloxymethyl-2,4-dihydroxy-butyl)-acetamide 
• 174541-89-0 (2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-hydroxypyrrolidine 
• 166383-69-3 (2R,3R)-1-t-Butoxycarbonyl-2-benzyloxymethyl-3-hydroxypyrrolidine 
• 174541-88-9 (2R,3S)-1-(tert-butoxycarbonyl)-2-(benzyloxymethyl)-3-<(4-nitrobenzoyl)oxy>-pyrrolidine 
• 166383-82-0 (2R,3R)-2-Benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 98900-30-2 (2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidinium hydrochloride 
• 567-35-1 (2S,3R)-3-hydroxyproline 
• 174541-87-8 (2R,3R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-5-<(β-naphthyl)sulphonyloxy>-3-pentanol 

Relevant articles and documents

A straightforward synthesis of (2S,3R)-3-hydroxyproline and trans-(2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine

A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)-2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has been introduced by a modified Mitsunobu reaction.