174689-39-5 Usage
Description
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE is a complex organic compound with a unique chemical structure. It is characterized by its ethylphenoxy and naphthalenylamine functional groups, which contribute to its specific properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE is used as a pharmaceutical compound for the identification and characterization of specific receptors, such as β-adrenoceptors in rat aorta. Its unique structure allows it to interact with these receptors, providing valuable insights into their function and potential therapeutic targets.
Used in Cardiology:
In the field of cardiology, 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE has been tested as a potential therapeutic agent for improving cardiac function in a rat model of heart failure. Its ability to modulate specific receptors and pathways may contribute to its potential efficacy in treating heart failure and related conditions.
Hazard
A poison.
Biological Activity
Potent and selective β 3 adrenoceptor antagonist (IC 50 values are 40, 408 and 648 nM for β 3 , β 1 and β 2 receptors respectively). Orally active in vivo . Also available as part of the β -Adrenoceptor Antagonist Tocriset? .
Biochem/physiol Actions
SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.1 It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.2
Check Digit Verification of cas no
The CAS Registry Mumber 174689-39-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,6,8 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174689-39:
(8*1)+(7*7)+(6*4)+(5*6)+(4*8)+(3*9)+(2*3)+(1*9)=185
185 % 10 = 5
So 174689-39-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
174689-39-5Relevant articles and documents
Synthesis of all of the stereoisomers of β3-adrenoceptor antagonist SR 59230 based on the spontaneous resolution of 3-(2-ethylphenoxy)propane-1,2-diol
Bredikhina, Zemfira A.,Kurenkov, Alexey V.,Krivolapov, Dmitry B.,Bredikhin, Alexander A.
, p. 467 - 474 (2016/06/06)
Racemic 3-(2-ethylphenoxy)propane-1,2-diol 2 has been effectively resolved into (S)- and (R)-enantiomers by a preferential crystallization procedure. Non-racemic diols 2, obtained via a Mitsunobu reaction, have been converted into the non-racemic 1,2-epox
