174699-04-8Relevant articles and documents
Preparation of Argatroban Analog Thrombin Inhibitors with Reduced Basic Guanidine Moiety, and Studies of Their Cell Permeability and Antithrombotic Activities
Kim, Kyoung Soon,Moquin, Robert V.,Qian, Ligang,Morrison, Richard A.,Seiler, Steven M.,Roberts, Daniel G. M.,Ogletree, Martin L.,Youssef, Sonia,Chong, Saeho
, p. 377 - 383 (2007/10/03)
To improve the oral absorption of thrombin inhibitors, Argatroban analogs 1, 2, 3 and 4, with reduced guanidine basicity were prepared. The in vitro thrombin inhibitory potency and their permeability of the Caco-2 cell monolayers were studied as a model f