174740-20-6

Basic information

• Product Name: (S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester
• Synonyms: (S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester
• CAS NO: 174740-20-6
• Molecular Weight: 801.163
• Mol File: 174740-20-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester(174740-20-6)
• EPA Substance Registry System: (S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Acetoxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid methyl ester(174740-20-6)

Safety Data

• Hazardous Substances Data: 174740-20-6(Hazardous Substances Data)

Upstream product

• 748122-53-4 C₁₁H₂₅NO₂Si 
• 1002-57-9 8-Aminooctanoic acid 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 150841-42-2 N-[3β-hydroxy-lup-20(29)-en-28-oyl]-8-aminooctanoic acid 

Downstream Products

• 150840-66-7 (S)-2-{8-[((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-Hydroxy-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-icosahydro-cyclopenta[a]chrysene-3a-carbonyl)-amino]-octanoylamino}-3-phenyl-propionic acid 

Relevant articles and documents

Betulinic acid derivatives: A new class of specific inhibitors of human immunodeficiency virus type 1 entry

A novel series of ω-aminoalkanoic acid derivatives of betulinic acid were synthesized and evaluated for their activity against human immunodeficiency virus (HIV). The anti-HIV-1 activity of several members of this new series was found to be in the nanomolar range in CEM 4 and MT-4 cell cultures. The optimization of the ω-aminoalkanoic acid side chain is described. The presence of an amide function within the side chain was found important for optimal activity. RPR 103611 (14g), a statine derivative, was found to be inactive against HIV-1 protease, reverse transcriptase, and integrase as well as on gp120/CD4 binding. 'Time of addition' experiments suggested interaction with an early step of HIV-1 replication. As syncytium formation, but not virus-cell binding, seems to be affected, betulinic acid derivatives are assumed to interact with the postbinding virus-cell fusion process.