174969-89-2

Basic information

• Product Name: Phosphonic acid, [(4-methylphenyl)methyl]-, bis(1,1-dimethylethyl) ester
• CAS NO: 174969-89-2
• Molecular Formula: C16H27O3P
• Molecular Weight: 298.362
• Mol File: 174969-89-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [(4-methylphenyl)methyl]-, bis(1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [(4-methylphenyl)methyl]-, bis(1,1-dimethylethyl) ester(174969-89-2)
• EPA Substance Registry System: Phosphonic acid, [(4-methylphenyl)methyl]-, bis(1,1-dimethylethyl) ester(174969-89-2)

Safety Data

• Hazardous Substances Data: 174969-89-2(Hazardous Substances Data)

Upstream product

• 13086-84-5 di-tert-butyl phosphite 
• 104-81-4 4-Methylbenzyl bromide 
• 13086-84-5 di-tert-butyl phosphite 

Downstream Products

• 174969-98-3 2-(Benzhydrylidene-amino)-3-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-propionic acid ethyl ester 
• 174969-90-5 ethyl 4-(di-tert-butylphosphonomethyl)-D,L-phenylalaninate 
• 597564-62-0 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-[4'-(di-tert-butylphosphonomethyl)benzyl]-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 257628-04-9 L-4-((di-tert-butyl)phosphonomethyl)phenylalanine 
• 166409-74-1 (4-bromomethylbenzyl)phosphonic acid di-tert-butyl ester 

Relevant articles and documents

Enantioselective synthesis of N-Fmoc protected di-tert-butyl 4-phosphonomethyl-L-phenylalanine: A hydrolytically stable analogue of O-phosphotyrosine

Fmoc-L-Pmp(tBu)2-OH was prepared with high enantiomeric purity by an asymmetric synthetic pathway, using a camphor sultam as chiral auxiliary.

Mild and efficient Cs2CO3-promoted synthesis of phosphonates

A mild and convenient synthesis for phosphonates using cesium carbonate (Cs2CO3), tetrabutylammonium iodide (TBAI) and DMF was developed at room temperature. Numerous dialkyl phosphites were screened using a diverse array of alkyl halides and these reaction conditions were found to be highly efficient producing various phosphonates exclusively in moderate to high yields.