17507-05-0 Usage
Description
1-Phenyl-1,2-dihydroisoquinolin-3(4H)-one is an organic compound belonging to the isoquinolinone family. It is characterized by its unique molecular structure, featuring a phenyl group attached to a dihydroisoquinolinone core. 1-phenyl-1,2-dihydroisoquinolin-3(4H)-one has attracted interest in various fields due to its potential applications and properties.
Uses
Used in Pharmaceutical Industry:
1-Phenyl-1,2-dihydroisoquinolin-3(4H)-one is used as a reagent for the synthesis of a series of 1-aryl-3-dimethylamino-1,4-dihydroisoquinolines, which exhibit anti-arthritic activity. Its role in the development of these compounds makes it a valuable component in the pharmaceutical industry, particularly for the treatment of arthritis-related conditions.
Additionally, 1-Phenyl-1,2-dihydroisoquinolin-3(4H)-one is utilized as a reagent in the synthesis of 1-aryl-1,4-dihydro-3(2H)-isoquinolinones. These synthesized compounds have potential antiserotoninergic activity, which can be beneficial in the development of medications targeting serotonin-related disorders.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 30, p. 381, 1993 DOI: 10.1002/jhet.5570300216
Check Digit Verification of cas no
The CAS Registry Mumber 17507-05-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,5,0 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 17507-05:
(7*1)+(6*7)+(5*5)+(4*0)+(3*7)+(2*0)+(1*5)=100
100 % 10 = 0
So 17507-05-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H13NO/c17-14-10-12-8-4-5-9-13(12)15(16-14)11-6-2-1-3-7-11/h1-9,15H,10H2,(H,16,17)
17507-05-0Relevant articles and documents
A convenient synthesis of 1-substituted 1,4-dihydroisoquinolin-3-ones
Barbry, Didier,Sokolowski, Guillaume,Champagne, Philippe
, p. 1787 - 1790 (2002)
A number of isoquinolin-3-ones have been obtained in fair to good yields by reaction of phenylacetonitrile with carbonyl compounds in PPA.
1-Aryl-1,4-dihydro-3(2H)-isoquinolinones: Two modes of interaction with 5-HT(1A) receptors
Mokrosz,Duszynska,Wesolowska,Borycz,Chojnacka-Wojcik,Karolak-Wojciechowska
, p. 58 - 68 (2007/10/03)
Two series of 1-aryl-1,4-dihydro-3(2H)-isoquinoline derivatives were synthesized, and their in vitro and in vivo properties at 5-HT(1A) and 5- HT(2A) receptors were evaluated. In was shown that series a, containing a 1- (m-chlophenyl)piperazine fragment, interacts with 5-HT(1A) receptors in two different modes: as an ordinary 4-substituted 1-arylpiperazine and as a pseudo one. Series b, with a 1,2,3,4-tetrahydroisoquinoline moiety, binds to the receptor thanks to a pseudo 1-arylpiperazine fragment. Regardless of the mode of interaction, both those series demonstrated 5-HT(1A) receptor antagonistic properties in animal models. Different in vivo properties of 2b, due to a 7-methoxy substituent, indicate that the isoquinolinone portion also interacts with 5-HT(1A) receptors.
Substituted 1,4-dihydro-1-phenylisoquinolin-3(2H)-ones as inhibitors of cyclic nucleotide phosphodiesterases from dog heart
St Georgiev,Van Inwegen,Carlson
, p. 375 - 378 (2007/10/02)
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