175131-61-0

Basic information

• Product Name: (1R-cis)-Milnacipran Hydrochloride
• Synonyms: (1R-cis)-Milnacipran Hydrochloride;cis-(-)-Milnacipran Hydrochloride
• CAS NO: 175131-61-0
• Molecular Formula: C15H23ClN2O
• Molecular Weight: 282.80892
• Product Categories: Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 175131-61-0.mol
• Article Data: 20

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1R-cis)-Milnacipran Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1R-cis)-Milnacipran Hydrochloride(175131-61-0)
• EPA Substance Registry System: (1R-cis)-Milnacipran Hydrochloride(175131-61-0)

Safety Data

• Hazardous Substances Data: 175131-61-0(Hazardous Substances Data)

Usage

Description

(1R-cis)-Milnacipran Hydrochloride, also known as M344600, is the R-enantiomer of Milnacipran. It is a selective norepinephrine and serotonin reuptake inhibitor (SNRI) that has been approved for the management of fibromyalgia.

Uses

Used in Pharmaceutical Industry:
(1R-cis)-Milnacipran Hydrochloride is used as a therapeutic agent for the treatment of fibromyalgia. It works by inhibiting the reuptake of norepinephrine and serotonin, which helps to alleviate the symptoms of this chronic pain disorder.
Additionally, as a selective norepinephrine and serotonin reuptake inhibitor, (1R-cis)-Milnacipran Hydrochloride may also have potential applications in the treatment of other conditions related to neurotransmitter imbalances, such as depression and anxiety. However, further research and clinical trials would be necessary to establish its efficacy and safety in these areas.

Upstream product

• 1237261-65-2 (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide-cyclopropanecarboxamide 
• 74-89-5 methylamine 
• 1374648-80-2 (1S,2R)-cis-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (D)-(-)-mandelate 
• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 1374648-84-6 (1R,2S)-cis-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide (L)-(+)-mandelate 
• 96847-54-0 (1R,2S)-milnacipran 
• 105310-75-6 (1SR,2RS)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropane carboxamide 

Relevant articles and documents

Drug intermediate as well as preparation and application thereof

The invention designs a drug intermediate III, and the structural formula of the drug intermediate III is shown in the specification.

Preparation of leveminacipran hydrochloride

The invention discloses a novel preparation method for synthesizing leveminacipran hydrochloride, and relates to a compound represented by a formula A. According to the invention, each step of reaction is simple in operation and mild in condition, use of

Preparation method of levomilnacipran hydrochloride

The invention relates to the field of chemical medicines and organic synthesis and in particular relates to a preparation method of levomilnacipran hydrochloride. Aiming at solving the problems of anexisting method for preparing the levomilnacipran hydrochloride that the cost is relatively high or a generation process is relatively dangerous so that large-scale industrial production is limited, the preparation method is characterized by comprising the following steps: [1] enabling phenylacetonitrile and (R)-2-chloromethyl ethylene oxide to react under the action of sodium amide to obtain a compound 1; then carrying out hydrolysis cyclization on the compound 1 to obtain a compound 2; [2] enabling the compound 2 and thionyl chloride to react in alcohol, so as to obtain a compound 3; [3] enabling the compound 3 to be subjected to exchange reaction through introducing nitryl and amino, so as to obtain a compound 6; [4] reducing nitryl in the compound 6 and forming salt in situ to obtain the levomilnacipran hydrochloride. The preparation method provided by the invention is applicable to industrial production of the levomilnacipran hydrochloride.