175135-79-2

Basic information

• Product Name: 2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE
• Synonyms: BUTTPARK 91\14-07;2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE;2-(4-methylphenoxy)nicotinoyl chloride
• CAS NO: 175135-79-2
• Molecular Formula: C₁₃H₁₀ClNO₂
• Molecular Weight: 247.68
• Mol File: 175135-79-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 353.9 °C at 760 mmHg
• Flash Point: 167.8 °C
• Appearance: /
• Density: 1.264 g/cm³
• Vapor Pressure: 3.47E-05mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE(175135-79-2)
• EPA Substance Registry System: 2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE(175135-79-2)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 175135-79-2(Hazardous Substances Data)

Usage

General Description

2-(4-Methylphenoxy)pyridine-3-carbonyl chloride, also known as 4-(3-Chloro-2-pyridyloxy)toluene, is a chemical compound commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is a carbonyl chloride derivative of 2-(4-methylphenoxy)pyridine-3-carboxylic acid, and is often used as a reagent in organic synthesis to introduce the carbonyl chloride functional group into organic molecules. 2-(4-METHYLPHENOXY)PYRIDINE-3-CARBONYL CHLORIDE is also known for its versatile reactivity and ability to undergo various chemical reactions, making it a valuable building block in the production of pharmaceuticals and other organic compounds. However, it is important to handle this compound with caution as it is a reactive and potentially hazardous chemical.

InChI:InChI=1/C13H10ClNO2/c1-9-4-6-10(7-5-9)17-13-11(12(14)16)3-2-8-15-13/h2-8H,1H3

Upstream product

• 106-44-5 p-cresol 
• 2942-59-8 2-chloronicotinic acid 
• 54629-15-1 2-p-tolyloxy-nicotinic acid 

Relevant articles and documents

Design, Synthesis, and Herbicidal Activity of Novel Diphenyl Ether Derivatives Containing Fast Degrading Tetrahydrophthalimide

To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle of substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is the most potential compound, with the half-maximal inhibitory concentration (IC50) value of 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize PPO and similar herbicidal activities to Oxyfluorfen in weeding experiments in greenhouses and field weeding experiments. In view of the inspected bioactivities, the structure-activity relationship (SAR) of this series of compounds was also discussed. Crop selection experiments demonstrate that compound 6c is safe for soybeans, maize, rice, peanuts, and cotton at a dose of 300 g ai/ha. Accumulation analysis experiments showed that the accumulation of 6c in some crops (soybeans, peanuts, and cotton) was significantly lower than Oxyfluorfen. Current work suggests that compound 6c may be developed as a new herbicide candidate in fields.