175153-18-1

Basic information

• Product Name: RARECHEM AL BE 1405
• Synonyms: RARECHEM AL BE 1405;2-Methoxy-4-phenylbenzoic acid
• CAS NO: 175153-18-1
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.24
• Mol File: 175153-18-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: RARECHEM AL BE 1405(CAS DataBase Reference)
• NIST Chemistry Reference: RARECHEM AL BE 1405(175153-18-1)
• EPA Substance Registry System: RARECHEM AL BE 1405(175153-18-1)

Safety Data

• Hazardous Substances Data: 175153-18-1(Hazardous Substances Data)

Upstream product

• 175152-70-2 methyl 3-methoxy-[1,1‘-biphenyl]-4-carboxylate 
• 72135-36-5 4-bromo-2-methoxybenzoic acid 
• 98-80-6 phenylboronic acid 
• 78955-90-5 methyl 4-chloro-2-methoxybenzoate 
• 139102-34-4 methyl 4-bromo-2-methoxybenzoate 
• 343603-82-7 3-methoxy-[1,1'-biphenyl]-4-carbaldehyde 

Downstream Products

• 201149-85-1 N-(2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-2-methoxy-4-phenylbenzamide, Hydrochloride 
• 1426095-68-2 1,1-dimethylethyl (3RS)-[({[3-(methyloxy)-4-biphenylyl]carbonyl}amino)methyl]-1-pyrrolidinecarboxylate 
• 1426095-69-3 N-methyl-3-(methyloxy)-N-(3(RS)-pyrrolidinylmethyl)-4-biphenylcarboxamide 
• 1426094-95-2 N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of L-amino alcohol derivatives as broad-spectrum antifungal agents

To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alcohol derivatives were designed and synthesized. 3-F substituted compounds 14i, 14n, 14s and 14v exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03–0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1–2 μg/mL. Notably, Compounds 14i, 14n, 14s and 14v also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 14v stemmed from inhibition of C. albicans CYP51. Compounds 14n and 14v were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.

FATTY ACID SYNTHASE INHIBITORS

This invention relates to carboxamides and reverse carboxamides according to Formula (I) and the use of carboxamides and reverse carboxamides for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of carboxamides and reverse carboxamides in the treatment of cancer.

NF-KB ACTIVATION INHIBITORS

A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.