175214-93-4

Basic information

• Product Name: C₁₇H₁₉NO₅S
• Synonyms: C₁₇H₁₉NO₅S
• CAS NO: 175214-93-4
• Molecular Weight: 349.408
• Mol File: 175214-93-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₉NO₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₉NO₅S(175214-93-4)
• EPA Substance Registry System: C₁₇H₁₉NO₅S(175214-93-4)

Safety Data

• Hazardous Substances Data: 175214-93-4(Hazardous Substances Data)

Upstream product

• 27513-44-6 N-tert-butoxycarbonyl-O-benzyl-(S)-tyrosine methyl ester 
• 100-44-7 benzyl chloride 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 174701-15-6 4-benzyloxy-N-methanesulfonyl-phenylalanine-methylester 

Downstream Products

• 1398115-18-8 C₁₇H₂₀N₂O₅S 

Relevant articles and documents

Design, synthesis and evaluation of novel metalloproteinase inhibitors based on l-tyrosine scaffold

A series of novel l-tyrosine derivatives were designed, synthesized and assayed for their inhibitory activities on matrix metalloproteinase 2 (MMP-2) and histone deacetylase 8 (HDAC-8). The results showed that these l-tyrosine derivatives exhibited inhibitory profiles against MMP-2 and HDAC-8. The compounds 6h (IC50 = 0.013 ± 0.001 μM) and 6j (IC 50 = 0.017 ± 0.001 μM) were equal potent MMP-2 inhibitors to the positive control NNGH (IC50 = 0.014 ± 0.001 μM). As for HDAC-8 inhibition, some of the hydroxamate compounds, such as 6d (IC 50 = 3.6 ± 0.2 μM) and 6c (IC50 = 5.8 ± 0.5 μM), were equal potent to the positive control SAHA (IC50 = 1.6 ± 0.1 μM). Structure-activity relationships were also briefly discussed.