175277-85-7 Usage
General Description
N1-(3-eth-1-ynylphenyl)-2-chloroacetamide is a chemical compound with the molecular formula C10H9ClNO. It is a derivative of acetamide, with a chlorine atom attached to the second carbon of the acetamide group and a phenyl group attached to the nitrogen atom. The ethynyl group is attached to the phenyl group at the ortho position. N1-(3-ETH-1-YNYLPHENYL)-2-CHLOROACETAMIDE has potential applications in the field of medicinal chemistry, particularly in the development of new pharmaceuticals. It may also have uses in the synthesis of other organic compounds. However, further research and testing would be necessary to fully understand its potential uses and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 175277-85-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,7 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 175277-85:
(8*1)+(7*7)+(6*5)+(5*2)+(4*7)+(3*7)+(2*8)+(1*5)=167
167 % 10 = 7
So 175277-85-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H8ClNO/c1-2-8-4-3-5-9(6-8)12-10(13)7-11/h1,3-6H,7H2,(H,12,13)
175277-85-7Relevant articles and documents
Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of α-glucosidase inhibition, docking, and kinetic studies
Faramarzi, Mohammad Ali,Firoozpour, Loghman,Foroumadi, Alireza,Moghimi, Setareh,Mojtabavi, Somayeh,Sadat Ebrahimi, Seyed Esmaeil,Safari, Fatemeh,Salarinejad, Somayeh,Toolabi, Mahsa
, (2020)
We herein applied the four step-synthetic route to prepare the pyridazine core attached to the various N-aryl acetamides. By this approach, a new series of pyridazine-based compounds were synthesized, characterized and evaluated for their activities against α-glucosidase enzyme. In-vitro α-glucosidase assay established that twelve compounds are more potent than acarbose. Compound 7a inhibited α-glucosidase with the IC50 value of 70.1 μM. The most potent compounds showed no cytotoxicity against HDF cell line. Molecular docking and kinetic studies were performed to determine the modes of interaction and inhibition, respectively.
