175278-18-9

Basic information

• Product Name: 4-BROMO-2-(TRIFLUOROMETHOXY)ACETANILIDE
• Synonyms: N1-[4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL]ACETAMIDE;BUTTPARK 91\57-38;4'-BROMO-2'-(TRIFLUOROMETHOXY)ACETANILIDE;4-BROMO-2-(TRIFLUOROMETHOXY)ACETANILIDE;2-acetamido-5-bromo(trifluoromethoxy)benzene;4'-Bromo-2'-(trifluoromethoxy)acetanilide 97%;4'-Bromo-2'-(trifluoromethoxy)acetanilide97%;4'-Bromo-2'-(Tr
• CAS NO: 175278-18-9
• Molecular Formula: C₉H₇BrF₃NO₂
• Molecular Weight: 298.06
• Product Categories: Anilines, Amides & Amines;Bromine Compounds;Fluorine Compounds
• Mol File: 175278-18-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 135 °C
• Boiling Point: 302.4 °C at 760 mmHg
• Flash Point: 136.7 °C
• Appearance: /
• Density: 1.664 g/cm³
• Storage Temp.: Room temperature.
• PKA: 13.20±0.70(Predicted)
• CAS DataBase Reference: 4-BROMO-2-(TRIFLUOROMETHOXY)ACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(TRIFLUOROMETHOXY)ACETANILIDE(175278-18-9)
• EPA Substance Registry System: 4-BROMO-2-(TRIFLUOROMETHOXY)ACETANILIDE(175278-18-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 175278-18-9(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(trifluoromethoxy)acetanilide is a specialized chemical substance that belongs to the organic compound family. 4-BROMO-2-(TRIFLUOROMETHOXY)ACETANILIDE features a unique structure with one bromine atom (Bromo), a trifluoromethoxy group (-OCHF3), and an acetanilide moiety. These elements are bonded together to form a complex structure that fits within the category of organic amides. Important information to be aware of regarding this chemical includes its molecular formula which is C9H8BrF3NO2, as well as its molar mass, which is approximately 304.07 g/mol. Like many organic compounds, it may have biochemical and pharmaceutical research applications, but specific properties like toxicity, reactivity, physical characteristics such as boiling point, melting point, and others primarily depend on its purity and how it is handled or stored.

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Relevant articles and documents

Selective C-O bond formation: Via a photocatalytic radical coupling strategy: Access to perfluoroalkoxylated (ORF) arenes and heteroarenes

Development of an efficient process that employs commercially available and cost effective reagents for the synthesis of perfluoroalkoxylated aromatic compounds (Ar-ORF) remains a daunting challenge in organic synthesis. Herein, we report the first catalytic protocol using readily available perfluoroalkyl iodides (RFI) and N-(hetero)aryl-N-hydroxylamides to access a wide range of perfluoroalkoxylated (hetero)arenes. Mild reaction conditions allow for selective O-RF bond formation over a broad substrate scope and are tolerant of a wide variety of functional groups. Mechanistic studies suggest the formation and recombination of persistent N-hydroxyl radicals and transient RF radicals under photocatalytic reaction conditions to generate N-ORF compounds that rearrange to afford the desired products.

TRIFLUOROMETHOXYLATION OF ARENES VIA INTRAMOLECULAR TRIFLUOROMETHOXY GROUP MIGRATION

The present invention provides a process of producing a trifluoromethoxylated aryl or trifluoromethoxylated heteroaryl having the structure: (I), wherein A is an aryl or heteroaryl, each with or without subsutitution; and R1 is -H, -(alkyl), -(alkenyl), -(alkynyl), -(aryl), -(heteroaryl), - (alkylaryl), - (alkylheteroaryl), -NH-(alkyl), -N(alkyl)2, -NH-(alkenyl), -NH-(alkynyl) -NH-(aryl), -NH-(heteroaryl), -O-(alkyl), -O-(alkenyl), -O-(alkynyl), -O-(aryl), -O-(heteroaryl), -S-(alkyl), -S- (alkenyl), -S-(alkynyl), -S-(aryl), or -S-(heteroaryl), comprising: (a) reacting a compound having the structure: (II), with a trifluoromethylating agent in the presence of a base in a first suitable solvent under conditions to produce a compound having the structure: (III); and (b) maintaining the compound produced in step (a) in a second suitable solvent under conditions sufficient to produce the trifluoromethoxylated aryl or trifluormethoxylated heteroaryl having the structure: (I).

SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may