175288-46-7

Basic information

• Product Name: [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (S)-indan-1-yl ester
• Synonyms: [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (S)-indan-1-yl ester
• CAS NO: 175288-46-7
• Molecular Weight: 501.741
• Mol File: 175288-46-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (S)-indan-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (S)-indan-1-yl ester(175288-46-7)
• EPA Substance Registry System: [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (S)-indan-1-yl ester(175288-46-7)

Safety Data

• Hazardous Substances Data: 175288-46-7(Hazardous Substances Data)

Upstream product

• 175288-41-2 N-<2-(tert-butyldiphenylsilyloxy)ethyl>-N-isopropylamine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 25501-32-0 (S)-indanol 
• 175288-42-3 N-<2-(tert-butyldiphenylsilyloxy)ethyl>-N-isopropylcarbamoyl chloride 
• 109-56-8 i-propyl(2-(hydroxy)ethyl)amine 

Downstream Products

• 175288-55-8 (S)-1-{[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamoyloxy}-indan-1-carboxylic acid methyl ester 
• 175288-56-9 [2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-isopropyl-carbamic acid (R)-1-(1-hydroxy-1-methyl-ethyl)-indan-1-yl ester 

Relevant articles and documents

Synthesis of enantioenriched tertiary benzylic alcohols via stereospecific lithiation of secondary benzyl carbamates - Design of dialkylcarbamates, cleavable under basic, mild conditions

Enantiomerically enriched, secondary benzyl N-[2-(tert-butyldiphenylsilyloxy)ethyl]-N-isopropylcarbamates were prepared, lithiated, and stereospecifically substituted by several electrophiles. Deprotection under basic conditions furnished optically active tertiary benzylic alcohols and glycols or 2-hydroxy-2-arylalkanoic acid esters. In summary, the sequence achieves the stereospecific chain elongation of d1-synthons, derived from secondary benzyl alcohols.