175352-88-2

Basic information

• Product Name: Phosphorous acid cyclohexyl ester dimethyl ester
• CAS NO: 175352-88-2
• Molecular Weight: 192.195
• Mol File: 175352-88-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phosphorous acid cyclohexyl ester dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphorous acid cyclohexyl ester dimethyl ester(175352-88-2)
• EPA Substance Registry System: Phosphorous acid cyclohexyl ester dimethyl ester(175352-88-2)

Safety Data

• Hazardous Substances Data: 175352-88-2(Hazardous Substances Data)

Upstream product

• 868-85-9 Dimethyl phosphite 
• 108-93-0 cyclohexanol 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 199116-11-5 C₁₀H₂₃O₃PSi 
• 1932-60-1 methylphosphonic acid monocyclohexyl ester 
• 7040-52-0 cyclohexyl methyl methylphosphonate 

Relevant articles and documents

Organophosphorus chemistry. Part 1: The synthesis of alkyl methylphosphonic acids

Several alkyl hydrogen methylphosphonates of structure RO(HO)P(O)Me were synthesised by a three-stage route [R =i-Pr, n-Bu, i-Bu, s-Bu, pinacolyl Me3C-CH(Me)-, cyclopentyl and cyclohexyl]. Trimethyl phosphite was transesterified with alcohols in the presence of sodium catalyst to give the mixed phosphites (MeO)2POR in 6-64% yield. Treatment of these with methyl iodide gave alkyl methyl methylphosphonates RO(MeO)P(O)Me in 66-95% yield. Selective demethylation of these compounds by bromotrimethylsilane, followed by methanolysis of the phosphorus silyl esters RO(Me3SiO)P(O)Me, gave the hydrogen phosphonates in 60-97% yield.