175355-72-3

Basic information

• Product Name: 3-(phenylthio)quinolin-2(1H)-one
• Synonyms: 3-(phenylthio)quinolin-2(1H)-one
• CAS NO: 175355-72-3
• Molecular Weight: 253.324
• Mol File: 175355-72-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(phenylthio)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(phenylthio)quinolin-2(1H)-one(175355-72-3)
• EPA Substance Registry System: 3-(phenylthio)quinolin-2(1H)-one(175355-72-3)

Safety Data

• Hazardous Substances Data: 175355-72-3(Hazardous Substances Data)

Upstream product

• 22615-00-5 3-bromoquinoline N-oxide 
• 5332-24-1 3-bromoquinoline 
• 939-16-2 3-bromoquinolin-2-one 
• 108-98-5 thiophenol 
• 175355-70-1 1-(methoxymethyl)-3,4-dihydroquinolin-2(1H)-one 
• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 175355-71-2 1-Methoxymethyl-3-phenylsulfanyl-1H-quinolin-2-one 
• 144-48-9 iodacetamide 
• 930-69-8 sodium thiophenolate 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 175355-73-4 Carbonic acid methyl ester 3-phenylsulfanyl-quinolin-2-yl ester 
• 175355-74-5 2-Oxo-3-phenylsulfanyl-2H-quinoline-1-carboxylic acid methyl ester 

Relevant articles and documents

Enantioselective Synthesis of Diaryl Sulfoxides Enabled by Molecular Recognition

The enantioselective sulfoxidation of diaryl-type sulfides was accomplished using a chiral manganese porphyrin complex equipped with a remote molecular recognition site. Despite the marginal size difference between the two substituents at the prostereogen

One-pot copper-catalyzed three-component reaction: A modular approach to functionalized 2-quinolones

A copper-catalyzed three-component annulation for the synthesis of functionalized 2-quinolones was developed. Three reactions including an SN2, a Knoevenagel, and finally C-N bond formation are involved in the designed cascade reaction using 2-bromoacylarenes, 2-iodoacetamide, and nucleophiles as the three components. A new catalytic system was discovered during the study and this modular approach is highly efficient to access functionalized 2-quinolone derivatives, compatible with a broad range of functional groups, scalable, and step-economic. Further derivatization of the obtained product demonstrates the synthetic utility of this method.