175481-26-2

Basic information

• Product Name: LacosaMide (raceMate)
• Synonyms: LacosaMide (raceMate)
• CAS NO: 175481-26-2
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.29362
• Mol File: 175481-26-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 536.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• Vapor Pressure: 0Pa at 25℃
• PKA: 14.19±0.46(Predicted)
• CAS DataBase Reference: LacosaMide (raceMate)(CAS DataBase Reference)
• NIST Chemistry Reference: LacosaMide (raceMate)(175481-26-2)
• EPA Substance Registry System: LacosaMide (raceMate)(175481-26-2)

Safety Data

• Hazardous Substances Data: 175481-26-2(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 55299-56-4 N-acetyl serine methyl ester 
• 80-48-8 methyl p-toluene sulfonate 
• 171623-02-2 (R,S)-N-acetylserine-N-benzylamide 
• 175481-36-4 (2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide 
• 98632-99-6 O-Methyl-N-acetyl-DL-serine 
• 108-24-7 acetic anhydride 
• 262845-82-9 N-Benzyl-2-Amino-3-Methoxypropionamide 
• 175481-29-5 methyl α-acetamido-N-benzylmalonamate 
• 58685-35-1 α-acetamido-N-benzyl-α-cyanoacetamide 
• 74-88-4 methyl iodide 

Downstream Products

• 175481-36-4 (2S)-2-(acetylamino)-N-benzyl-3-methoxypropanamide 
• 175481-36-4 lacosamide 
• 1318767-66-6 C₈H₇ClO₃*C₁₁H₁₆N₂O₂ 
• 262845-82-9 N-Benzyl-2-Amino-3-Methoxypropionamide 

Relevant articles and documents

High-efficiency racemic lacosamide preparation method

The invention discloses a high-efficiency racemic lacosamide preparation method. The preparation method is characterized in that N-acetyl serine shown in a formula (II) is utilized as a raw material and completely reacts with methyl bromide under the action of sodium hydride to obtain 2-acetamido-3-methoxy methyl propionate shown in a formula (III), and then the 2-acetamido-3-methoxy methyl propionate generates ester exchange reaction with benzylamine under the catalyst of trifluoromethanesulfonate to obtain a product namely racemic lacosamide. The suspended lacosamide preparation method disclosed by the invention has an industrial process route which has the advantages of short reaction line, high yield, high atom utilization rate, simpleness in aftertreatment and low cost.

PROCESS FOR THE SYNTHESIS OF LACOSAMIDE

A novel process for the synthesis of Lacosamide using D,L-serine as starting material is described, where the methylation reaction of hydroxyl is carried out using an inexpensive base such as NaOH and an inexpensive alkylating agent, non-toxic and non-car

Anticonvulsant enantiomeric amino acid derivatives

The present invention is directed to a compound in the R configuration about the asymmetric carbon in the following formula: STR1 pharmaceutical compositions containing same and the use thereof in treating CNS disorders in animals.