1755-45-9

Basic information

• Product Name: Butanal, 2-(phenylmethylene)-, (2E)-
• Synonyms: E-2-ethyl-3-phenylpropenal;(E)-2-benzylidenebutanal;α-ethyl cinnamaldehyde;2-Ethyl-3-phenyl-2-propenal;2-ethyl-3t-phenyl-acrylaldehyde
• CAS NO: 1755-45-9
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Mol File: 1755-45-9.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Butanal, 2-(phenylmethylene)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanal, 2-(phenylmethylene)-, (2E)-(1755-45-9)
• EPA Substance Registry System: Butanal, 2-(phenylmethylene)-, (2E)-(1755-45-9)

Safety Data

• Hazardous Substances Data: 1755-45-9(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 30989-75-4 ethoxy-1 formyl-2 butene-1 
• 904295-65-4 α,α-bis(trimethylsilyl)-N-tert-butylbutyraldimine 
• 100-52-7 benzaldehyde 
• 201230-82-2 carbon monoxide 
• 622-76-4 1-phenyl-1-butyne 
• 536-74-3 phenylacetylene 
• 123-73-9 crotonaldehyde 
• 154581-93-8 (Z)-2-Trimethylsilanyl-1-trimethylsilanyloxy-but-1-ene 
• 5395-08-4 benzaldehyde di-n-butylacetal 
• 123-72-8 butyraldehyde 
• 25290-28-2 2-(α-ethoxy-benzyl)-butyraldehyde 
• 56407-97-7 (E)-2-benzylidenebutan-1-ol 
• 60754-33-8 (E)-ethyl 2-benzylidenebutanoate 

Downstream Products

• 56640-48-3 2-benzyl butanol 
• 3968-85-2 (2-methyl-butyl)-benzene 
• 24569-60-6 2-ethyl-3-phenylpropanal 

Relevant articles and documents

Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors

Leveraging the catalytic machinery of LSD1 (KDM1A), a series of covalent styrenylcyclopropane LSD1 inhibitors were identified. These inhibitors represent a new class of mechanism-based inhibitors that target and covalently label the FAD cofactor of LSD1.

Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes

Since its discovery in 1938, hydroformylation has been thoroughly investigated and broadly applied in industry (>107 metric ton yearly). However, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many synthetically valuable aldehydes. Pd-catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-processes. Here, we report a highly selective and exceptionally active catalyst system that is driven by a novel activation strategy and features a unique Pd(I)-Pd(I) mechanism, involving an iodide-assisted binuclear step to release the product. This method enables β-selective hydroformylation of a large range of alkenes and alkynes, including sensitive starting materials. Its utility is demonstrated in the synthesis of antiobesity drug Rimonabant and anti-HIV agent PNU-32945. In a broader context, the new mechanistic understanding enables the development of other carbonylation reactions of high importance to chemical industry.

INHIBITORS OF METALLO-BETA-LACTAMASES

The present invention relates to compounds of Formula (I) that function as inhibitors of bacterial metallo-beta-lactamases. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of a bacterial infection. (Formula (I))