17555-51-0 Usage
Type
Semisynthetic derivative of rifamycin S
Source
Derived from rifamycin S, an antibiotic produced by Amycolatopsis mediterranei bacterium
Classification
Rifamycin antibiotic
Mechanism of Action
Binds to the beta subunit of bacterial DNA-dependent RNA polymerase
Mode of Inhibition
Inhibits the transcription process
Antibacterial Activity
Potent antibacterial agent
Target Bacteria
Particularly effective against Gram-positive bacteria
Spectrum of Activity
Effective against various bacterial infections
Therapeutic Potential
Valuable component in the treatment of bacterial infections
Additional Therapeutic Applications
Potential treatment for tuberculosis and other mycobacterial infections
Check Digit Verification of cas no
The CAS Registry Mumber 17555-51-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,5,5 and 5 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 17555-51:
(7*1)+(6*7)+(5*5)+(4*5)+(3*5)+(2*5)+(1*1)=120
120 % 10 = 0
So 17555-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C35H43NO11/c1-15-10-9-11-16(2)34(44)36-21-14-22(37)24-25(31(21)42)30(41)20(6)32-26(24)33(43)35(7,47-32)46-13-12-23(45-8)17(3)28(39)19(5)29(40)18(4)27(15)38/h9-15,17-19,23,27-29,38-41H,1-8H3,(H,36,44)/b10-9+,13-12+,16-11+
17555-51-0Relevant articles and documents
DRUGS WITH ANTICHOLESTATIC ACTIVITY
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Page/Page column 10, (2010/07/08)
New compounds belonging to the structural formula (I) are described. in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.
Rifamycin analogs and uses thereof
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Page/Page column 44, (2008/06/13)
The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3′-hydroxy analogs, 4′- and/or 6′ halo and/or alkoxy analogs, and various 5′ substituents that incorporate a cyclic amine moiety.
