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175730-33-3

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175730-33-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 175730-33-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,7,3 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175730-33:
(8*1)+(7*7)+(6*5)+(5*7)+(4*3)+(3*0)+(2*3)+(1*3)=143
143 % 10 = 3
So 175730-33-3 is a valid CAS Registry Number.

175730-33-3Relevant articles and documents

Synthesis and characterization of new theophylline and chlordiazepoxide prodrug polymers based on maleimide

Abbas, Layali Abdullah,Kareem, Mohanad Mousa

, p. 2788 - 2792 (2018)

In this work, two new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized which loaded with medicinal properties to extend the controlled drug. The first step includes the preparation maleimic acid (L1) and (L2) via re

Preparation and Characterization of Hetero-bifunctional Cross-linking Reagents for Protein Modifications

Kitagawa, Tsunehiro,Shimozono, Takuro,Aikawa, Tadaomi,Yoshida, Toyokichi,Nishimura, Haruki

, p. 1130 - 1135 (2007/10/02)

Ten aromatic and aliphatic cross-linking reagents of hetero-bifunctional type were synthesized as part of a search for useful reagents of this type.All of the reagents possess two selectively reactive groups a maleimide group which can combine with a thiol group via its double bond and an N-Hydroxysuccinimidyl ester (one of the most hydrophilic active esters), which can react with an ammmine group.It was found that the active esters of the reagents tested were mostly more reactive with lysine than with leucine, and acylated amino acids more rapidly at pH 8.0 than at pH 7.0.It was also found that the stability of the maleimide group in the compounds tested depends largely upon the pH of the buffer used.The most stable pH was 5.0-6.0.To use one of the present compounds as a cross-linker, the crystalline reagent should be dissolved in tetrahydrofuran of dioxane and the solution used for cross-linking.The acylation step should be carried out first with thiol addition to the maleimide group as the second step.The optimum pH of the buffer used for the first step is slightly basic.The reaction time should be limited to less than 1 hr.When the first step is over, the pH of the reaction mixture should be changed to 5.0-6.0.Keywords---cross-linker; hetero-bifunctional reagent; reactivity of N-hydroxy-succinimidyl ester; stability of maleimide residue; N-(maleimidobenzoyloxy)succinimide derivative; N-(maleimidoalkyloxy)succinimide derivative

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