175739-42-1

Basic information

• Product Name: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
• CAS NO: 175739-42-1
• Molecular Formula: C₂₂H₂₄N₂O₃
• Molecular Weight: 364.4376
• Mol File: 175739-42-1.mol
• Article Data: 3

Chemical Properties

• Density: 1.172g/cm³
• Refractive Index: 1.582
• CAS DataBase Reference: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione(175739-42-1)
• EPA Substance Registry System: 6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione(175739-42-1)

Safety Data

• Hazardous Substances Data: 175739-42-1(Hazardous Substances Data)

Usage

General Description

6-benzyl-1-[(benzyloxy)methyl]-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione, also known as BzPMPD, is a chemical compound that belongs to the class of pyrimidine derivatives. It contains a benzyl group, a benzyloxy group, and a propan-2-yl group attached to the pyrimidine ring. BzPMPD has been studied for its potential pharmacological activities, including its anti-inflammatory and anti-hypertensive properties. It has also been researched for its potential use as a precursor in the development of new pharmaceutical drugs. The chemical structure and properties of BzPMPD make it an interesting target for further investigation in the field of medicinal chemistry.

Upstream product

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• 100-51-6 benzyl alcohol 

Relevant articles and documents

New efficient and flexible synthetic route to Emivirine and its analogs

A revised synthetic route to Emivirine (MKC-442) via properly substituted β-keto ester converted from Meldrum's Acid was developed. This method could be applied to the synthesis of a variety of MKC-442 analogues and open the way for their systematic biological evaluation.

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). Inhibitors with a novel structure core are essential for combating resistance associated with known IN inhibitors (INIs). We have previously disclosed a novel dual inhibitor scaffold of HIV IN and reverse transcriptase (RT). Here we report the complete structure-activity relationship (SAR), molecular modeling, and resistance profile of this inhibitor type on IN inhibition. These studies support an antiviral mechanism of dual inhibition against both IN and RT and validate 3-hydroxypyrimidine-2,4-diones as an IN inhibitor scaffold.