175777-31-8

Basic information

• Product Name: (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one
• Synonyms: (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one
• CAS NO: 175777-31-8
• Molecular Weight: 281.354
• Mol File: 175777-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one(175777-31-8)
• EPA Substance Registry System: (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one(175777-31-8)

Safety Data

• Hazardous Substances Data: 175777-31-8(Hazardous Substances Data)

Upstream product

• 175659-77-5 (αR)-N-[2-hydroxy-1-phenylethyl]-1,4-dihydro-2H-isoquinolin-3-one 
• 74-88-4 methyl iodide 

Downstream Products

• 213821-84-2 (αR,4S)-[N-(2-hydroxy-1-phenylethyl)-4-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid ter-butyl ester 
• 213821-76-2 (αR,4S)-N-[4-(2-hydroxyethyl)-4-methyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenylethanol 
• 213821-81-9 (αR,4S)-4-(4-chlorobutyl)-N-(2-hydroxy-1-phenylethyl)-4-methyl-1,4-dihydro-2H-isoquinolin-3-one 

Relevant articles and documents

4,4'-disubstituted 1,2,3,4-tetrahydroisoquinolines from alkylation of a chiral non racemic lactam. An approach to the crinine-type alkaloids

Enantiomerically pure 4,4-disubstituted tetrahydroisoquinolin-3-ones can be easily prepared by bis-alkylation of 1,2,3,4-tetrahyroisoquinolin-3-one 1 derived from (R)-(-)phenylglycinol. The observed diastereoselectivity was explained by a rigid chelated i