175796-45-9

Basic information

• Product Name: Benzoic acid, 4-hydroxy-3-methoxy-, 1-methylethyl ester
• CAS NO: 175796-45-9
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Mol File: 175796-45-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-hydroxy-3-methoxy-, 1-methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-hydroxy-3-methoxy-, 1-methylethyl ester(175796-45-9)
• EPA Substance Registry System: Benzoic acid, 4-hydroxy-3-methoxy-, 1-methylethyl ester(175796-45-9)

Safety Data

• Hazardous Substances Data: 175796-45-9(Hazardous Substances Data)

Upstream product

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 401840-67-3 isopropyl 3-methoxy-4-(trifluoromethanesulphonyloxy)benzoate 

Relevant articles and documents

Structure–activity relationships of vanillic acid ester analogs in inhibitory effect of antigen-mediated degranulation in rat basophilic leukemia RBL-2H3 cells

Methyl vanillate (1) showed strong degranulation inhibitory activity among vanillin derivatives tested. In order to find structure–activity relationships for developing anti-allergic agents with simple structures and potent activity, we synthesized several vanillic acid (VA) ester derivatives with C1–C4and C8alkyl chains and evaluated their degranulation inhibitory activities. The most active compound of VA ester derivatives was derivative 5 with a C4straight alkyl chain, and derivative 5 exhibited approximately three-fold greater inhibitory activity than that of 1. Moreover, we designed 8 types of analogs based on 5, and we found that the minimum structure for potent degranulation inhibitory activity requires direct connection of the butyl ester moiety on the benzene ring and at least one hydroxyl group on the benzene ring. Butyl meta or para hydroxyl benzoate (10 or 11) has a simpler structure than that of 5 and exhibited more potent degranulation inhibitory activity than that of 5.

Vanillic acid ester perfuming agents

The vanillic acid esters, for example, methyl or ethyl vanillate, are effective perfuming or olfactory agents for a wide variety of compositions, substrates and articles, whether perfumes, skin- and haircare products, cosmetics, shaving preparations, toiletries, deodorants and antiperspirants, room deodorizers, etc.