175878-36-1Relevant articles and documents
2-[(Alkylsulfonyl)oxy]-6-substituted-1H-isoindole-1,3(2H)-dione mechanism-based inhibitors of human leukocyte elastase
Kerrigan, John E.,Shirley, Jennifer J.
, p. 451 - 456 (1996)
Derivatives of 2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3(2H)-diones (N-sulfonyloxy)phthalimides) with ring substituents in the 6-position were found to exhibit enhanced inhibitory potency and selectivity for HLE. The most potent inhibitor of HLE in this ser
6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism- based inhibitors of human leukocyte elastase
Kerrigan, John E.,Walters, Matthew C.,Forrester, Kerri J.,Crowder, Jason B.,Christopher, Lisa J.
, p. 27 - 30 (2007/10/03)
A study of various 2-[(alkylsulfonyl)oxy]-6-substituted-1H-isoindole- 1,3-diones' inhibition of chymotrypsin compared to inhibition of HLE reveals that acylamino substitution in the 6-position increases selectivity and potency of these inhibitors for HLE.
