17591-06-9

Basic information

• Product Name: 1,2-DIMETHYL-5-METHOXYINDOLE
• Synonyms: 1,2-DIMETHYL-5-METHOXYINDOLE;AKOS JY2082557;5-METHOXY-1,2-DIMETHYLINDOLE
• CAS NO: 17591-06-9
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 17591-06-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 316°C at 760 mmHg
• Flash Point: 136.8°C
• Appearance: /
• Density: 1.324g/cm³
• Vapor Pressure: 9.02E-05mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: 1,2-DIMETHYL-5-METHOXYINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIMETHYL-5-METHOXYINDOLE(17591-06-9)
• EPA Substance Registry System: 1,2-DIMETHYL-5-METHOXYINDOLE(17591-06-9)

Safety Data

• Hazardous Substances Data: 17591-06-9(Hazardous Substances Data)

Usage

General Description

1,2-DIMETHYL-5-METHOXYINDOLE is a chemical compound with the molecular formula C11H13NO. It is a derivative of the naturally occurring compound indole, which is commonly found in plant and animal tissues. 1,2-DIMETHYL-5-METHOXYINDOLE is a pale yellow liquid with a strong odor, and it is often used as a fragrance ingredient in perfumes and personal care products. It has also been studied for its potential applications in pharmaceuticals, particularly in the development of new drugs for various medical conditions. Additionally, 1,2-DIMETHYL-5-METHOXYINDOLE has been investigated for its role in biological systems, particularly in the regulation of neurotransmitters and hormone levels in the body.

InChI:InChI=1/C8H15BrO2/c9-7-5-3-1-2-4-6-8(10)11/h1-7H2,(H,10,11)

Upstream product

• 1076-74-0 5-methoxy-2-methyl-1H-indole 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 940-11-4 N-methyl-N-nitroso-p-anisidine 
• 67-64-1 acetone 
• 35292-54-7 N-methyl-N-(p-methoxyphenyl)hydrazine 
• 40963-98-2 ethyl 5-methoxy-1,2-dimethyl-1H-indole-3-carboxylate 
• 106698-10-6 1-(5-methoxy-2-methyl-1H-indol-1-yl)ethanone 
• 51-66-1 4-methoxyacetanilide 

Downstream Products

• 113369-47-4 2-chloro-1-(1,2-dimethyl-5-methoxy-3-indolyl)ethanone 
• 25888-06-6 1,2-Dimethyl-5-hydroxyindole 
• 34572-28-6 5-methoxy-1,2-dimethylindole-3-carboxaldehyde 
• 1383453-96-0 3-(5-methoxy-1,2-dimethyl-1H-indol-3-yl)-1-phenyl-4-(3-thienyl)-1H-pyrrole-2,5-dione 
• 1383453-97-1 3-(5-methoxy-1,2-dimethyl-1H-indol-3-yl)-1-(4-methylphenyl)-4(3-thienyl)-1H-pyrrole-2,5-dione 
• 1383453-98-2 3-(5-methoxy-1,2-dimethyl-1H-indol-3-yl)-1-(4-methoxyphenyl)-4-(3-thienyl)-1H-pyrrole-2,5-dione 
• 1383453-99-3 1-(4-chlorophenyl)-3-(5-methoxy-1,2-dimethyl-1H-indol-3-yl)-4-(3-thienyl)-1H-pyrrole-2,5-dione 
• 1383454-00-9 1-benzyl-3-(5-methoxy-1,2-dimethyl-1H-indol-3-yl)-4-(3-thienyl)-1H-pyrrole-2,5-dione 

Relevant articles and documents

Cu-Catalyzed Oxidation of C2 and C3 Alkyl-Substituted Indole via Acyl Nitroso Reagents

The selective oxidation of C2-alkyl-substituted indoles to 3-oxindole and the selective C-H oxygenation or amination of C2,C3-dialkyl-substituted indoles at C2 are reported under mild conditions. The position of the alkyl substitution on the indole directs the reaction to different pathways under similar conditions.

Ring-Opening Diarylation of Siloxydifluorocyclopropanes by Ag(I) Catalysis: Stereoselective Construction of 2-Fluoroallylic Scaffold

A silver-catalyzed, defluorination ring-opening diarylation of siloxy 2,2-difluorocyclopropanes, with two arenes, to directly prepare polysubstituted 2-fluoroallylic compounds, is described. This multicomponent reaction proceeds smoothly in good stereoselectivity, which is due to a chelation-controlled addition of arenes to α-fluorinated ketone intermediate.

Synthesis of indoles through Rh(III)-catalyzed C-H cross-coupling with allyl carbonates

A practical Rh-catalyzed reaction was developed to achieve 2-alkyl-substituted indole synthesis. The reaction can tolerate a variety of synthetically important functional groups. The indole products can also be transformed into other important skeletons. Two bioactive compounds, that is indomethacin and pravadoline were prepared using the new method.