175979-81-4Relevant articles and documents
Enantioselective alkylation of lactams and lactones via lithium enolate formation using a chiral tetradentate lithium amide in the presence of lithium bromide
Matsuo, Jun-Ichi,Kobayashi, Shu,Koga, Kenji
, p. 9723 - 9726 (2007/10/03)
Enantioselective alkylation of lactams and lactones can be realized up to 98% ee by deprotonation with a chiral tetradentate lithium amide (4b) in the presence of lithium bromide, and subsequent alkylation with active alkylating agents in non-chelating solvents.