17610-14-9

Basic information

• Product Name: 1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone
• CAS NO: 17610-14-9
• Molecular Formula: C₁₅H₂₀O
• Molecular Weight: 216.3187
• Mol File: 17610-14-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 314.5°C at 760 mmHg
• Flash Point: 131°C
• Density: 0.953g/cm³
• Vapor Pressure: 0.000465mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: 1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone(17610-14-9)
• EPA Substance Registry System: 1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone(17610-14-9)

Safety Data

• Hazardous Substances Data: 17610-14-9(Hazardous Substances Data)

Usage

Description

1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone, also known as Iso E Super, is a synthetic ketone with a distinct woody aroma and a hint of cedarwood and floral notes. It is known for its long-lasting and skin-friendly scent, making it a popular ingredient in the fragrance industry.

Uses

Used in Fragrance Industry:
1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone is used as a base note in perfume compositions for its ability to enhance and prolong the overall fragrance profile.
Used in Aromatherapy and Wellness Products:
1-(1,1,3,3-tetramethyl-2,3-dihydro-1H-inden-5-yl)ethanone is used as a calming and stress-reducing agent in aromatherapy and wellness products due to its soothing effects.

Upstream product

• 606-23-5 1H-indene-1,3(2H)-dione 
• 4132-49-4 p-tert.-Butyl-cumol 
• 98-82-8 Isopropylbenzene 
• 7446-70-0 aluminium trichloride 
• 66564-05-4 5-tert-butyl-2,3-dihydro-1,1,3,3-tetramethyl-1H-indene 
• 98-95-3 nitrobenzene 
• 75-36-5 acetyl chloride 
• 4834-33-7 1,1,3,3-tetramethylindan 

Downstream Products

• 71441-27-5 4'-[(E)-2-(1,1,3,3-tetramethyl-5-indanyl)propenyl]-acetophenone 
• 69251-31-6 <1-(1,1,3,3-tetramethyl-5-indanyl)ethyl>-triphenylphosphonium bromide 
• 69251-08-7 2E-4E-7-(1,1,3,3-tetramethyl-5-indanyl)-3-methyl-octa-2,4,6-trienoic acid 
• 71441-07-1 p-<(E)-2-(1,1,3,3-tetramethyl-5-indanyl)-propenyl>-benzoic acid ethylester 

Relevant articles and documents

Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors

Retinoic acid receptor (RAR)-related orphan receptors (RORs) regulate a variety of physiological processes, including hepatic gluconeogenesis, lipid metabolism, circadian rhythm and immune function. The RAR agonist: all-trans retinoic acid was reported to be an RORβ inverse agonist, but no information is available regarding ROR activity of its synthetic analogue Am580. Therefore, we screened Am580 and some related tetramethyltetrahydronaphthalene derivatives and carried out structural development studies, including substitution of carbon atoms with silicon, with the aim of creating a potent ROR transcriptional inhibitor. The phenyl amide disila compound 22 showed the most potent ROR-inhibitory activity among the compounds examined. Its activity towards RORα, RORβ and RORγ was increased compared to that of Am580. The IC50 values for RORα, RORβ and RORγ are 1.3, >10 and 4.5 μM, respectively.